glt-4 Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: glt-4
Official Full Name: Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4
Primary source: WormBase:WBGene00001622
Locus tag: CELE_T22E5.2
See related: AllianceGenome:WB:WBGene00001622
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in head neurons and metacorpus. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria; episodic ataxia type 6; schizophrenia 18; and spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to several human genes including SLC1A1 (solute carrier family 1 member 1) and SLC1A6 (solute carrier family 1 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See glt-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (6403422..6408411)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

T22E5.2 (e-PCR)
- UniSTS:315056

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Amino acid transporter;Putative sodium-dependent excitatory amino acid transporter glt-4

NP_001379386.1

Confirmed by transcript evidence

NP_509075.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6403422..6408411

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076674.8 → NP_509075.3 Putative sodium-dependent excitatory amino acid transporter glt-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509075.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22682

Conserved Domains (1) summary

pfam00375
Location:10 → 454

SDF; Sodium:dicarboxylate symporter family
NM_001392788.1 → NP_001379386.1 Amino acid transporter [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7R9SUN6

Conserved Domains (1) summary

pfam00375
Location:10 → 454

SDF; Sodium:dicarboxylate symporter family