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    metr-1 putative methionine synthase [ Caenorhabditis elegans ]

    Gene ID: 174681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    metr-1
    Official Full Name
    putative methionine synthase
    Primary source
    WormBase:WBGene00010988
    Locus tag
    CELE_R03D7.1
    See related
    AllianceGenome:WB:WBGene00010988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable methionine synthase activity. Predicted to be involved in homocysteine metabolic process; methionine biosynthetic process; and tetrahydrofolate metabolic process. Predicted to be active in cytosol. Is expressed in hypodermis; intestine; and pharynx. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See metr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (10926561..10931078)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tubulin_C domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene DNA2/NAM7 helicase-like C-terminal domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. Liu YJ, et al. PLoS Genet, 2019 Mar. PMID 30845140, Free PMC Article
    2. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cabreiro F, et al. Cell, 2013 Mar 28. PMID 23540700, Free PMC Article
    3. Bacterial vitamin B(12) production enhances nematode predatory behavior. Akduman N, et al. ISME J, 2020 Jun. PMID 32152389, Free PMC Article
    4. Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits. Watson E, et al. Cell, 2014 Feb 13. PMID 24529378, Free PMC Article
    5. Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans. Hannich JT, et al. Dev Cell, 2009 Jun. PMID 19531354

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in homocysteine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pteridine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative methionine synthase
    NP_496353.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10926561..10931078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063952.5 → NP_496353.1  putative methionine synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09582
      Conserved Domains (5) summary
      COG0646
      Location:3 → 329
      MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
      PRK09490
      Location:1 → 1245
      metH; B12-dependent methionine synthase; Provisional
      cd00740
      Location:360 → 615
      MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
      cd02069
      Location:661 → 886
      methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
      pfam02965
      Location:954 → 1230
      Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09582.1

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