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    Zfp82 zinc finger protein 82 [ Mus musculus (house mouse) ]

    Gene ID: 330502, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp82provided by MGI
    Official Full Name
    zinc finger protein 82provided by MGI
    Primary source
    MGI:MGI:1890753
    See related
    Ensembl:ENSMUSG00000098022 AllianceGenome:MGI:1890753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mszf3; Krab16; Zfp-82; A030010D05
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZFP82 (ZFP82 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 1.3), CNS E18 (RPKM 1.2) and 23 other tissues See more
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    Genomic context

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    See Zfp82 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29755459..29772248, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30056034..30072823, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18498 Neighboring gene zinc finger protein 568 Neighboring gene STARR-seq mESC enhancer starr_18501 Neighboring gene zinc finger protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E8161 Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869 Neighboring gene zinc finger protein 260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice. Wang S, et al. Oncogene, 2021 Dec. PMID 34615997, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    5. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice.
      Title: ZNF545 loss promotes ribosome biogenesis and protein translation to initiate colorectal tumorigenesis in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 82
    Names
    zinc finger protein 545

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252519.1 → NP_001239448.1  zinc finger protein 82 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      BC060530, BX525285, BY127198, CD806198
      Consensus CDS
      CCDS59723.1
      UniProtKB/TrEMBL
      S4R1G9
      Related
      ENSMUSP00000138217.2, ENSMUST00000182546.8
      Conserved Domains (5) summary
      smart00349
      Location:6 → 49
      KRAB; krueppel associated box
      COG5048
      Location:136 → 495
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:308 → 328
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:321 → 345
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001253385.1 → NP_001240314.1  zinc finger protein 82 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct and significantly shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK037211, BY127198
      Consensus CDS
      CCDS59724.1
      UniProtKB/Swiss-Prot
      Q6P9Y7
      Related
      ENSMUSP00000138469.2, ENSMUST00000183190.2
      Conserved Domains (2) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      pfam01352
      Location:6 → 45
      KRAB; KRAB box

    3. NM_177889.5 → NP_808557.2  zinc finger protein 82 isoform 1

      See identical proteins and their annotated locations for NP_808557.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC060530, BX525285, BY127198
      Consensus CDS
      CCDS39876.1
      UniProtKB/Swiss-Prot
      Q6P9Y7, Q6ZPG0, Q8BIP1
      Related
      ENSMUSP00000079647.8, ENSMUST00000080834.15
      Conserved Domains (5) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      COG5048
      Location:166 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:351 → 375
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29755459..29772248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9Y7.1 GenPept UniProtKB/Swiss-Prot:Q6P9Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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