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    Zcchc18 zinc finger, CCHC domain containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 66995, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zcchc18provided by MGI
    Official Full Name
    zinc finger, CCHC domain containing 18provided by MGI
    Primary source
    MGI:MGI:1914245
    See related
    Ensembl:ENSMUSG00000031428 AllianceGenome:MGI:1914245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sizn2; 1500031H04Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; glans of male genital tubercle; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human ZCCHC18 (zinc finger CCHC-type containing 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 69.4), frontal lobe adult (RPKM 40.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zcchc18 in Genome Data Viewer
    Location:
    X F1; X 59.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135893128..135899221)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136992379..136998472)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene thymosin beta 15b2 Neighboring gene thymosin beta 15b like Neighboring gene thymosin beta 15b1 Neighboring gene solute carrier family 25, member 53 Neighboring gene vacuolar ATPase assembly integral membrane protein Vma21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47980 Neighboring gene family with sequence similarity 199, X-linked Neighboring gene predicted gene, 25770

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of proteins that interact with murine cytomegalovirus early protein M112-113 in brain. Wang H, et al. Chin Med J (Engl), 2011 Nov. PMID 22340173
    2. ISL1 controls pancreatic alpha cell fate and beta cell maturation. Bohuslavova R, et al. Cell Biosci, 2023 Mar 10. PMID 36899442, Free PMC Article
    3. eXPRESSION: an in silico tool to predict patterns of gene expression. Ferguson DA, et al. Gene Expr Patterns, 2005 Jun. PMID 15939374
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 18
    Names
    SMAD-interacting zinc finger protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035509.2 → NP_001030586.1  zinc finger CCHC domain-containing protein 18

      See identical proteins and their annotated locations for NP_001030586.1

      Status: VALIDATED

      Source sequence(s)
      AK075607, AK134856, AL672008, AL954296, AV174394, BC017627, BY261402
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Related
      ENSMUSP00000098788.3, ENSMUST00000101227.3
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    2. NM_001035510.2 → NP_001030587.1  zinc finger CCHC domain-containing protein 18

      See identical proteins and their annotated locations for NP_001030587.1

      Status: VALIDATED

      Source sequence(s)
      AK075607, AK134856, AL672008, AL954296, AV174394, BY261402
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Related
      ENSMUSP00000033804.5, ENSMUST00000033804.5
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    3. NM_001358437.1 → NP_001345366.1  zinc finger CCHC domain-containing protein 18

      Status: VALIDATED

      Source sequence(s)
      AK134856, AL672008, AL954296
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    4. NM_001358439.1 → NP_001345368.1  zinc finger CCHC domain-containing protein 18

      Status: VALIDATED

      Source sequence(s)
      AL672008, AL954296, BY283579
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    5. NM_001358440.1 → NP_001345369.1  zinc finger CCHC domain-containing protein 18

      Status: VALIDATED

      Source sequence(s)
      AL672008, AL954296
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    6. NM_001358441.1 → NP_001345370.1  zinc finger CCHC domain-containing protein 18

      Status: VALIDATED

      Source sequence(s)
      AL672008, AL954296
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    7. NM_025893.3 → NP_080169.2  zinc finger CCHC domain-containing protein 18

      See identical proteins and their annotated locations for NP_080169.2

      Status: VALIDATED

      Source sequence(s)
      AK005317, AK075607, AK134856, AL672008, AL954296, AV174394, BY261402
      Consensus CDS
      CCDS30427.1
      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Related
      ENSMUSP00000108690.2, ENSMUST00000113067.8
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135893128..135899221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251484.2 → XP_030107344.1  zinc finger CCHC domain-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA

    2. XM_030251485.2 → XP_030107345.1  zinc finger CCHC domain-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q8VD24, Q9DB17
      Conserved Domains (1) summary
      pfam14893
      Location:1 → 213
      PNMA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD24.1 GenPept UniProtKB/Swiss-Prot:Q8VD24

    Gene LinkOut

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