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    Izumo4 IZUMO family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 71564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Izumo4provided by MGI
    Official Full Name
    IZUMO family member 4provided by MGI
    Primary source
    MGI:MGI:1918814
    See related
    Ensembl:ENSMUSG00000055862 AllianceGenome:MGI:1918814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030607L17Rik
    Summary
    Predicted to be located in extracellular region. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human IZUMO4 (IZUMO family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 86.3), bladder adult (RPKM 15.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Izumo4 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80537858..80541216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80702015..80705382)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene MAP kinase-interacting serine/threonine kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80141015-80141203 Neighboring gene MOB kinase activator 3A Neighboring gene STARR-positive B cell enhancer ABC_E6884 Neighboring gene adaptor-related protein complex 3, delta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E368 Neighboring gene STARR-positive B cell enhancer ABC_E8348 Neighboring gene STARR-positive B cell enhancer ABC_E3900 Neighboring gene predicted gene, 53592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    izumo sperm-egg fusion protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027829.3 → NP_082105.3  izumo sperm-egg fusion protein 4 precursor

      See identical proteins and their annotated locations for NP_082105.3

      Status: VALIDATED

      Source sequence(s)
      BF682661, CAAA01118979, CB055593, CF105977
      Consensus CDS
      CCDS35983.1
      UniProtKB/Swiss-Prot
      D3Z690, Q6PEP3
      UniProtKB/TrEMBL
      A0A1X7SB79
      Related
      ENSMUSP00000151397.2, ENSMUST00000218184.2
      Conserved Domains (1) summary
      pfam15005
      Location:26 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80537858..80541216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314096.3 → XP_017169585.1  izumo sperm-egg fusion protein 4 isoform X11

      Conserved Domains (1) summary
      pfam15005
      Location:5 → 70
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    2. XM_006514134.3 → XP_006514197.1  izumo sperm-egg fusion protein 4 isoform X1

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    3. XM_006514136.3 → XP_006514199.1  izumo sperm-egg fusion protein 4 isoform X2

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    4. XM_036156017.1 → XP_036011910.1  izumo sperm-egg fusion protein 4 isoform X4

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 149
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    5. XM_017314090.2 → XP_017169579.1  izumo sperm-egg fusion protein 4 isoform X3

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    6. XM_006514138.3 → XP_006514201.1  izumo sperm-egg fusion protein 4 isoform X4

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 149
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    7. XM_017314095.3 → XP_017169584.1  izumo sperm-egg fusion protein 4 isoform X9

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    8. XM_006514143.3 → XP_006514206.1  izumo sperm-egg fusion protein 4 isoform X9

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    9. XM_030245283.2 → XP_030101143.1  izumo sperm-egg fusion protein 4 isoform X12

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    10. XM_006514145.3 → XP_006514208.1  izumo sperm-egg fusion protein 4 isoform X12

      Conserved Domains (1) summary
      pfam15005
      Location:27 → 150
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    11. XM_017314094.2 → XP_017169583.1  izumo sperm-egg fusion protein 4 isoform X8

      UniProtKB/TrEMBL
      A0A1X7SB79
      Conserved Domains (1) summary
      pfam15005
      Location:27 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    12. XM_017314092.2 → XP_017169581.1  izumo sperm-egg fusion protein 4 isoform X6

      UniProtKB/TrEMBL
      A0A1X7SB79
      Conserved Domains (1) summary
      pfam15005
      Location:27 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    13. XM_036156019.1 → XP_036011912.1  izumo sperm-egg fusion protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A1X7SB79
      Conserved Domains (1) summary
      pfam15005
      Location:27 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    14. XM_006514139.4 → XP_006514202.1  izumo sperm-egg fusion protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A1X7SB79
      Related
      ENSMUSP00000093076.5, ENSMUST00000095426.5
      Conserved Domains (1) summary
      pfam15005
      Location:27 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    15. XM_036156018.1 → XP_036011911.1  izumo sperm-egg fusion protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A1X7SB79
      Conserved Domains (1) summary
      pfam15005
      Location:27 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    16. XM_006514141.3 → XP_006514204.1  izumo sperm-egg fusion protein 4 isoform X7

      UniProtKB/TrEMBL
      A0A1X7SB79
      Conserved Domains (1) summary
      pfam15005
      Location:27 → 166
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    17. XM_030245284.2 → XP_030101144.1  izumo sperm-egg fusion protein 4 isoform X14

      Conserved Domains (1) summary
      pfam15005
      Location:1 → 70
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    18. XM_006514146.4 → XP_006514209.1  izumo sperm-egg fusion protein 4 isoform X13

      See identical proteins and their annotated locations for XP_006514209.1

      Conserved Domains (1) summary
      pfam15005
      Location:1 → 54
      IZUMO; Izumo sperm-egg fusion, Ig domain-associated

    RNA

    1. XR_001779600.3 RNA Sequence

    2. XR_003948804.1 RNA Sequence

    3. XR_001779602.2 RNA Sequence

    4. XR_001779603.2 RNA Sequence

    5. XR_003948806.1 RNA Sequence

    6. XR_003948805.2 RNA Sequence

    7. XR_001779601.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z690.1 GenPept UniProtKB/Swiss-Prot:D3Z690

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