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    Slurp2 secreted Ly6/Plaur domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 69462, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slurp2provided by MGI
    Official Full Name
    secreted Ly6/Plaur domain containing 2provided by MGI
    Primary source
    MGI:MGI:1916712
    See related
    Ensembl:ENSMUSG00000075605 AllianceGenome:MGI:1916712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLURP-2; 2300005B03Rik
    Summary
    Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor regulator activity. Acts upstream of or within keratinocyte proliferation. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Used to study palmoplantar keratosis. Orthologous to human SLURP2 (secreted LY6/PLAUR domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward stomach adult (RPKM 115.6) See more
    Orthologs
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    Genomic context

    See Slurp2 in Genome Data Viewer
    Location:
    15 D3; 15 34.27 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74614688..74618536, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (74742839..74746687, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 2 Neighboring gene predicted gene, 33124 Neighboring gene Ly6/neurotoxin 1 Neighboring gene lymphocyte antigen 6 family member D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine receptor regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine receptor regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetylcholine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    secreted Ly-6/uPAR domain-containing protein 2
    Names
    secreted Ly-6/uPAR-related protein 2
    secreted Ly6/uPAR related protein-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081961.1NP_001075430.1  secreted Ly-6/uPAR domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_001075430.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115610
      Consensus CDS
      CCDS37103.1
      UniProtKB/Swiss-Prot
      P0DP59
      Related
      ENSMUSP00000051457.7, ENSMUST00000057932.8
      Conserved Domains (1) summary
      pfam00021
      Location:2595
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      74614688..74618536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)