Taf10 TATA-box binding protein associated factor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf10provided by MGI
Official Full Name: TATA-box binding protein associated factor 10provided by MGI
Primary source: MGI:MGI:1346320
See related: Ensembl:ENSMUSG00000043866 AllianceGenome:MGI:1346320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 30kDa; Taf2h; TAFII30
Summary: Enables DNA binding activity and promoter-specific chromatin binding activity. Involved in several processes, including allantois development; chordate embryonic development; and protein-containing complex assembly. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; apoptotic process; and hepatocyte differentiation. Located in male germ cell nucleus. Part of transcription preinitiation complex. Is active in nucleus. Is expressed in several structures, including alimentary system; blastocyst; embryo mesenchyme; nervous system; and sensory organ epithelium. Orthologous to human TAF10 (TATA-box binding protein associated factor 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 258.4), duodenum adult (RPKM 245.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 55.97 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (105392101..105393550, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (105742894..105744375, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the TAF10-containing canonical TFIID and SAGA complexes are dispensable for early paraxial mesoderm development, arguing against the generic role in transcription proposed for these fully assembled holo-complexes
Title: The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.
By ablating TAF10 specifically in erythroid cells in vivo, observed is a differentiation block accompanied by deregulated GATA1 target genes, including Gata1 itself, suggesting functional cross talk between GATA1 and TAF10.
Title: TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.
TAF10 is required for TFIID stability, cell cycle progression, and transcription in the early mouse embryo
Title: TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice.
ablation of TAF10 in keratinocytes of the forming epidermis affects the expression of some, but not all genes, impairs keratinocyte terminal differentiation and alters skin permeability barrier functions
Title: TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ilk (e-PCR), detects polymorphism
- UniSTS:527395

AU041226 (e-PCR)
- UniSTS:180087

AA511515 (e-PCR), detects polymorphism
- UniSTS:143010

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in SAGA complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in allantois development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral mesodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SAGA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIID complex	TAS Traceable Author Statement more info	PubMed
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed
part_of transcription preinitiation complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 10

Names: TAF(II)30; TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kDa; TAFII-30; TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30 kDa; mTAFII30; transcription initiation factor TFIID 30 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418334.1 → NP_001405263.1 transcription initiation factor TFIID subunit 10 isoform 2

Status: VALIDATED

Source sequence(s)

AC121823
NM_020024.4 → NP_064408.2 transcription initiation factor TFIID subunit 10 isoform 1

See identical proteins and their annotated locations for NP_064408.2

Status: VALIDATED

Source sequence(s)

AC121823

Consensus CDS

CCDS21660.1

UniProtKB/Swiss-Prot

Q8C8H2, Q8K0H5, Q9QYY5

Related

ENSMUSP00000118105.2, ENSMUST00000141116.2

Conserved Domains (1) summary

cd07982
Location:115 → 217

TAF10; The TATA Binding Protein (TBP) Associated Factor 10