Nme7 NME/NM23 family member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nme7provided by MGI
Official Full Name: NME/NM23 family member 7provided by MGI
Primary source: MGI:MGI:2449121
See related: Ensembl:ENSMUSG00000026575 AllianceGenome:MGI:2449121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nm23-M7; Nm23-r7; nm23-H7; D530024H21Rik
Summary: Predicted to enable 3'-5' exonuclease activity and protein kinase activity. Involved in flagellated sperm motility. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; epithelial cilium movement involved in extracellular fluid movement; and intraciliary transport. Located in axonemal microtubule; centrosome; and ciliary basal body. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study hydrocephalus. Orthologous to human NME7 (NME/NM23 family member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 15.5), cortex adult (RPKM 15.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.2; 1 71.63 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (164135091..164264870)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (164307524..164437300)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nme6 or Nme7 can regulate several critical processes in embryonic stem cell renewal.
Title: A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal.
The nucleoside diphosphate kinase 7 in tracheal epithelia was found in the cell body but not in cilia and directly bind to microtubules.
Title: NDP kinase 7 is a conserved microtubule-binding protein preferentially expressed in ciliated cells.
situs inversus in Nme7-/- knockout mice
Title: Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.
Situs inversus and hydrocephalus observed in Nme7-/- mice
Title: Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234255

D1Mit203 (e-PCR), detects polymorphism
- UniSTS:128544

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:225347

BB495310 (e-PCR)
- UniSTS:207243

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within left/right pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in axonemal microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in axonemal microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	ISO Inferred from Sequence Orthology more info
part_of gamma-tubulin ring complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate kinase homolog 7; nucleoside diphosphate kinase 7

Names: 3'-5' exonuclease NME7; NDK 7; NDP kinase 7; NDP kinase homolog 7; non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase); nucleoside-diphosphate kinase; protein kinase NME7

NP_001280242.1

EC 2.7.4.6

NP_612187.2

EC 2.7.4.6

NP_835172.1

EC 2.7.4.6

XP_006496755.1

EC 2.7.4.6

XP_006496756.1

EC 2.7.4.6

XP_030107778.1

EC 2.7.4.6

XP_030107781.1

EC 2.7.4.6

XP_036018403.1

EC 2.7.4.6

XP_036018404.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293313.1 → NP_001280242.1 nucleoside diphosphate kinase homolog 7 isoform 1

See identical proteins and their annotated locations for NP_001280242.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK133221, BU609451

Consensus CDS

CCDS15436.2

UniProtKB/Swiss-Prot

Q3UMG6, Q9QXL8

UniProtKB/TrEMBL

Q80UP4

Related

ENSMUSP00000141431.2, ENSMUST00000191947.6

Conserved Domains (4) summary

smart00676
Location:22 → 110

DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases

smart00562
Location:111 → 244

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04412
Location:257 → 390

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:111 → 241

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
NM_138314.4 → NP_612187.2 nucleoside diphosphate kinase homolog 7 isoform 1

See identical proteins and their annotated locations for NP_612187.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.

Source sequence(s)

AK133221, BU609451

Consensus CDS

CCDS15436.2

UniProtKB/Swiss-Prot

Q3UMG6, Q9QXL8

UniProtKB/TrEMBL

Q80UP4

Related

ENSMUSP00000141963.2, ENSMUST00000193683.6

Conserved Domains (4) summary

smart00676
Location:22 → 110

DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases

smart00562
Location:111 → 244

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04412
Location:257 → 390

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:111 → 241

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
NM_178071.6 → NP_835172.1 nucleoside diphosphate kinase homolog 7 isoform 2

See identical proteins and their annotated locations for NP_835172.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to isoform 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK085222, AK133221

Consensus CDS

CCDS78731.1

UniProtKB/TrEMBL

Q8BUH2

Related

ENSMUSP00000083192.6, ENSMUST00000086028.6

Conserved Domains (4) summary

smart00676
Location:22 → 110

DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases

smart00562
Location:111 → 244

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04415
Location:111 → 241

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cl00335
Location:257 → 272

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

164135091..164264870

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496692.4 → XP_006496755.1 nucleoside diphosphate kinase 7 isoform X3

See identical proteins and their annotated locations for XP_006496755.1

UniProtKB/TrEMBL

Q05BM9

Conserved Domains (3) summary

cd04412
Location:202 → 335

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:56 → 186

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cl26962
Location:3 → 55

DUF1126; DUF1126 PH-like domain
XM_036162511.1 → XP_036018404.1 nucleoside diphosphate kinase 7 isoform X2

UniProtKB/TrEMBL

Q05BM9

Conserved Domains (3) summary

cd04412
Location:221 → 354

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:75 → 205

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cl26962
Location:22 → 74

DUF1126; DUF1126 PH-like domain
XM_006496693.5 → XP_006496756.1 nucleoside diphosphate kinase 7 isoform X3

See identical proteins and their annotated locations for XP_006496756.1

UniProtKB/TrEMBL

Q05BM9

Conserved Domains (3) summary

cd04412
Location:202 → 335

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:56 → 186

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cl26962
Location:3 → 55

DUF1126; DUF1126 PH-like domain
XM_030251918.2 → XP_030107778.1 nucleoside diphosphate kinase 7 isoform X3

UniProtKB/TrEMBL

Q05BM9

Conserved Domains (3) summary

cd04412
Location:202 → 335

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:56 → 186

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cl26962
Location:3 → 55

DUF1126; DUF1126 PH-like domain
XM_036162510.1 → XP_036018403.1 nucleoside diphosphate kinase 7 isoform X1

UniProtKB/TrEMBL

Q05BM9

Conserved Domains (3) summary

smart00676
Location:35 → 123

DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases

cd04412
Location:270 → 403

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:124 → 254

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
XM_030251921.2 → XP_030107781.1 nucleoside diphosphate kinase 7 isoform X3

UniProtKB/TrEMBL

Q05BM9

Conserved Domains (3) summary

cd04412
Location:202 → 335

NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cd04415
Location:56 → 186

NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...

cl26962
Location:3 → 55

DUF1126; DUF1126 PH-like domain