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    Mrrf mitochondrial ribosome recycling factor [ Mus musculus (house mouse) ]

    Gene ID: 67871, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mrrfprovided by MGI
    Official Full Name
    mitochondrial ribosome recycling factorprovided by MGI
    Primary source
    MGI:MGI:1915121
    See related
    Ensembl:ENSMUSG00000026887 AllianceGenome:MGI:1915121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RRF; MRFF; MTRRF; 2400002D02Rik
    Summary
    Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosome disassembly and translation. Located in mitochondrion. Orthologous to human MRRF (mitochondrial ribosome recycling factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.0), heart adult (RPKM 14.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrrf in Genome Data Viewer
    Location:
    2 B; 2 24.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (36025672..36080296)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (36135660..36190284)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox protein 6 Neighboring gene RNA binding motif protein 18 Neighboring gene predicted gene, 46735 Neighboring gene STARR-positive B cell enhancer ABC_E5908 Neighboring gene prostaglandin-endoperoxide synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
    2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosome-recycling factor, mitochondrial
    Names
    ribosome-releasing factor, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026422.2 → NP_080698.1  ribosome-recycling factor, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080698.1

      Status: VALIDATED

      Source sequence(s)
      AK010018, BX293557, BY320901, CX237338
      Consensus CDS
      CCDS38114.1
      UniProtKB/Swiss-Prot
      B1B055, Q9D6S7
      Related
      ENSMUSP00000028250.3, ENSMUST00000028250.9
      Conserved Domains (1) summary
      pfam01765
      Location:99 → 260
      RRF; Ribosome recycling factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      36025672..36080296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251998.1 → XP_030107858.1  ribosome-recycling factor, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam01765
      Location:12 → 169
      RRF; Ribosome recycling factor

    2. XM_017319228.2 → XP_017174717.1  ribosome-recycling factor, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam01765
      Location:62 → 208
      RRF; Ribosome recycling factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D6S7.1 GenPept UniProtKB/Swiss-Prot:Q9D6S7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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