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    Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 19108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prkxprovided by MGI
    Official Full Name
    protein kinase, X-linkedprovided by MGI
    Primary source
    MGI:MGI:1309999
    See related
    Ensembl:ENSMUSG00000035725 AllianceGenome:MGI:1309999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKX1; Pkare
    Summary
    Predicted to enable cAMP-dependent protein kinase activity. Involved in angiogenesis; cell adhesion; and endothelial cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; cardiovascular system; central nervous system; gonad; and gut. Orthologous to several human genes including PRKX (protein kinase cAMP-dependent X-linked catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 7.5), CNS E18 (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prkx in Genome Data Viewer
    Location:
    X B; X 38.32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (76804578..76839545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (77760972..77796235, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene SET translocation pseudogene Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 pseudogene Neighboring gene probasin Neighboring gene predicted gene 14744

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Man to mouse--lessons learned from the distal end of the human X chromosome. Blaschke RJ, et al. Genome Res, 1997 Dec. PMID 9414316
    2. A novel murine PKA-related protein kinase involved in neuronal differentiation. Blaschke RJ, et al. Genomics, 2000 Mar 1. PMID 10729225
    3. Profiles of PrKX expression in developmental mouse embryo and human tissues. Li W, et al. J Histochem Cytochem, 2005 Aug. PMID 15879576
    4. PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Li X, et al. Dev Biol, 2011 Aug 15. PMID 21684272
    5. Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency. Li X, et al. Biochim Biophys Acta, 2008 Jan. PMID 17980165

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis.
      Title: PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cAMP-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-substrate adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial tube morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in kidney morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of epithelial cell differentiation involved in kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase catalytic subunit PRKX
    Names
    PKA-related protein kinase
    putative serine/threonine kinase
    serine/threonine-protein kinase PRKX
    NP_001398615.1
    NP_001398616.1
    NP_001398618.1
    NP_001398621.1
    NP_001398623.1
    NP_001398630.1
    NP_001398631.1
    NP_001398632.1
    NP_001398633.1
    NP_058675.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411686.1 → NP_001398615.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL714017
      UniProtKB/TrEMBL
      Q3UDT1

    2. NM_001411687.1 → NP_001398616.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL714017
      UniProtKB/TrEMBL
      Q3UDT1

    3. NM_001411689.1 → NP_001398618.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL714017
      UniProtKB/TrEMBL
      Q3UDT1

    4. NM_001411692.1 → NP_001398621.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL714017
      UniProtKB/TrEMBL
      Q3UDT1

    5. NM_001411694.1 → NP_001398623.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL714017

    6. NM_001411701.1 → NP_001398630.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL714017

    7. NM_001411702.1 → NP_001398631.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL714017

    8. NM_001411703.1 → NP_001398632.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL714017

    9. NM_001411704.1 → NP_001398633.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL714017

    10. NM_016979.2 → NP_058675.1  cAMP-dependent protein kinase catalytic subunit PRKX isoform 1

      See identical proteins and their annotated locations for NP_058675.1

      Status: VALIDATED

      Source sequence(s)
      AK034681, AK037141, AK143039, BE943829, BG074563, CJ136116
      Consensus CDS
      CCDS30248.1
      UniProtKB/Swiss-Prot
      B1AVU0, Q3UCD1, Q8BHD6, Q922R0, Q9QZ12
      UniProtKB/TrEMBL
      Q3UDT1
      Related
      ENSMUSP00000045304.8, ENSMUST00000036333.14
      Conserved Domains (2) summary
      PTZ00263
      Location:31 → 355
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd05612
      Location:44 → 335
      STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      76804578..76839545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922R0.1 GenPept UniProtKB/Swiss-Prot:Q922R0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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