Plpp6 phospholipid phosphatase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plpp6provided by MGI
Official Full Name: phospholipid phosphatase 6provided by MGI
Primary source: MGI:MGI:1921661
See related: Ensembl:ENSMUSG00000040105 AllianceGenome:MGI:1921661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ppapdc2; 4932443D16Rik
Summary: Predicted to enable isoprenoid diphosphate phosphatase activity and phosphatase activity. Predicted to be involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be active in membrane. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and skin. Orthologous to human PLPP6 (phospholipid phosphatase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 23.61 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (28941320..28944201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (28963920..28966801)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128654 (e-PCR)
- UniSTS:211962

AW122618 (e-PCR)
- UniSTS:166141

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables isoprenoid diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables isoprenoid diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lipid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in farnesyl diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesyl diphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in geranyl diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in geranyl diphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in geranylgeranyl diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in geranylgeranyl diphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phospholipid dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein prenylation	ISO Inferred from Sequence Orthology more info
involved_in protein prenylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

Names: phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; presqualene diphosphate phosphatase

NP_083198.1

EC 3.6.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028922.3 → NP_083198.1 polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

See identical proteins and their annotated locations for NP_083198.1

Status: VALIDATED

Source sequence(s)

AK016572, AK149181, BC052412

Consensus CDS

CCDS29728.1

UniProtKB/Swiss-Prot

Q9D4F2

Related

ENSMUSP00000047776.3, ENSMUST00000045674.4

Conserved Domains (2) summary

COG0671
Location:204 → 266

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03391
Location:115 → 273

PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...