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    Ints10 integrator complex subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 70885, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ints10provided by MGI
    Official Full Name
    integrator complex subunit 10provided by MGI
    Primary source
    MGI:MGI:1918135
    See related
    Ensembl:ENSMUSG00000031864 AllianceGenome:MGI:1918135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921521J11Rik
    Summary
    Predicted to be involved in snRNA processing. Predicted to be located in nucleus. Predicted to be part of integrator complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and spinal cord. Orthologous to human INTS10 (integrator complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.4), testis adult (RPKM 15.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints10 in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69245729..69282062)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68793929..68829410)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene SH2 domain containing 4A Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_21708 Neighboring gene STARR-seq mESC enhancer starr_21710 Neighboring gene STARR-positive B cell enhancer mm9_chr8:71151041-71151341 Neighboring gene STARR-positive B cell enhancer ABC_E5009 Neighboring gene STARR-seq mESC enhancer starr_21711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71317593-71317892 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene predicted gene, 51577 Neighboring gene lipoprotein lipase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 10
    Names
    int10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293791.2 → NP_001280720.1  integrator complex subunit 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123813
      Consensus CDS
      CCDS80885.1
      UniProtKB/TrEMBL
      E9Q360, E9Q361
      Related
      ENSMUSP00000105871.2, ENSMUST00000110242.8

    2. NM_001293792.2 → NP_001280721.1  integrator complex subunit 10 isoform 2

      See identical proteins and their annotated locations for NP_001280721.1

      Status: VALIDATED

      Source sequence(s)
      AC123813
      Consensus CDS
      CCDS80886.1
      UniProtKB/TrEMBL
      A0A0R4J0V1, E9Q361
      Related
      ENSMUSP00000069908.2, ENSMUST00000070713.8

    3. NM_001359129.2 → NP_001346058.1  integrator complex subunit 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123813
      UniProtKB/TrEMBL
      E9Q361

    4. NM_027590.5 → NP_081866.1  integrator complex subunit 10 isoform 3

      See identical proteins and their annotated locations for NP_081866.1

      Status: VALIDATED

      Source sequence(s)
      AC123813
      Consensus CDS
      CCDS22342.1
      UniProtKB/Swiss-Prot
      Q8BYC2, Q8BZI9, Q8K2A7, Q9D5U1
      UniProtKB/TrEMBL
      E9Q361
      Related
      ENSMUSP00000034328.7, ENSMUST00000034328.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      69245729..69282062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509741.4 → XP_006509804.1  integrator complex subunit 10 isoform X1

      UniProtKB/TrEMBL
      E9Q361

    2. XM_006509743.5 → XP_006509806.1  integrator complex subunit 10 isoform X2

      UniProtKB/TrEMBL
      E9Q361

    3. XM_006509747.5 → XP_006509810.1  integrator complex subunit 10 isoform X5

      UniProtKB/TrEMBL
      E9Q361

    4. XM_036154289.1 → XP_036010182.1  integrator complex subunit 10 isoform X4

      UniProtKB/TrEMBL
      E9Q361

    5. XM_006509744.5 → XP_006509807.1  integrator complex subunit 10 isoform X3

      UniProtKB/TrEMBL
      E9Q361

    6. XM_036154290.1 → XP_036010183.1  integrator complex subunit 10 isoform X6

      UniProtKB/TrEMBL
      E9Q361
      Related
      ENSMUSP00000105870.2, ENSMUST00000110241.8

    7. XM_011242326.3 → XP_011240628.1  integrator complex subunit 10 isoform X7

      UniProtKB/TrEMBL
      E9Q361

    8. XM_030243763.2 → XP_030099623.1  integrator complex subunit 10 isoform X9

    9. XM_030243764.2 → XP_030099624.1  integrator complex subunit 10 isoform X10

    10. XM_030243765.1 → XP_030099625.1  integrator complex subunit 10 isoform X11

    11. XM_036154291.1 → XP_036010184.1  integrator complex subunit 10 isoform X8

    RNA

    1. XR_004934877.1 RNA Sequence

    2. XR_004934876.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2A7.3 GenPept UniProtKB/Swiss-Prot:Q8K2A7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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