Gpr156 G protein-coupled receptor 156 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr156provided by MGI
Official Full Name: G protein-coupled receptor 156provided by MGI
Primary source: MGI:MGI:2653880
See related: Ensembl:ENSMUSG00000046961 AllianceGenome:MGI:2653880
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gababl
Summary: Predicted to enable G protein-coupled GABA receptor activity. Involved in stereocilium bundle organization. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; mammary gland; and trachea. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human GPR156 (G protein-coupled receptor 156). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E14 (RPKM 1.9), whole brain E14.5 (RPKM 1.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 26.54 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (37736551..37827892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (37916185..38007530)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia.
Title: EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled GABA receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in stereocilium bundle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable G-protein coupled receptor 156

Names: GABAB-related G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153394.2 → NP_700443.2 probable G-protein coupled receptor 156

See identical proteins and their annotated locations for NP_700443.2

Status: PROVISIONAL

Source sequence(s)

BC059227

Consensus CDS

CCDS28162.1

UniProtKB/Swiss-Prot

Q6PCP7, Q8K452

UniProtKB/TrEMBL

A0A0R4J0P3

Related

ENSMUSP00000055958.8, ENSMUST00000061274.9

Conserved Domains (2) summary

TIGR00599
Location:347 → 538

rad18; DNA repair protein rad18

pfam00003
Location:71 → 141

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

37736551..37827892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245894.4 → XP_011244196.1 probable G-protein coupled receptor 156 isoform X2

Conserved Domains (2) summary

cd14964
Location:48 → 73

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:48 → 315

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006522126.1 → XP_006522189.1 probable G-protein coupled receptor 156 isoform X1

Conserved Domains (3) summary

TIGR00599
Location:87 → 278

rad18; DNA repair protein rad18

cd14964
Location:26 → 51

7tm_GPCRs; TM helix 7 [structural motif]

cl28897
Location:1 → 57

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily