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    Rdh14 retinol dehydrogenase 14 (all-trans and 9-cis) [ Mus musculus (house mouse) ]

    Gene ID: 105014, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rdh14provided by MGI
    Official Full Name
    retinol dehydrogenase 14 (all-trans and 9-cis)provided by MGI
    Primary source
    MGI:MGI:1920402
    See related
    Ensembl:ENSMUSG00000020621 AllianceGenome:MGI:1920402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAN2; 3110030G19Rik
    Summary
    Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinol metabolic process. Located in mitochondrion. Orthologous to human RDH14 (retinol dehydrogenase 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 13.1), adrenal adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rdh14 in Genome Data Viewer
    Location:
    12 A1.1; 12 5.29 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (10440752..10445562)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (10390748..10395562)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5319 Neighboring gene 5'-nucleotidase, cytosolic IB Neighboring gene predicted gene, 38407 Neighboring gene STARR-seq mESC enhancer starr_31530 Neighboring gene STARR-seq mESC enhancer starr_31531 Neighboring gene STARR-seq mESC enhancer starr_31532 Neighboring gene predicted gene 4928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RDH13L, an enzyme responsible for the aldehyde-alcohol redox coupling reaction (AL-OL coupling reaction) to supply 11-cis retinal in the carp cone retinoid cycle. Sato S, et al. J Biol Chem, 2015 Jan 30. PMID 25533474, Free PMC Article
    2. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. Haeseleer F, et al. J Biol Chem, 2002 Nov 22. PMID 12226107, Free PMC Article
    3. Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. Lee J, et al. Mol Cell Proteomics, 2007 Apr. PMID 17208939, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 11-cis-retinol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables steroid dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retinol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 14
    Names
    alcohol dehydrogenase PAN2
    alcohol dehydrogenase PAN2; expressed sequence AW215439
    NP_076186.1
    XP_006515006.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023697.2 → NP_076186.1  retinol dehydrogenase 14

      See identical proteins and their annotated locations for NP_076186.1

      Status: VALIDATED

      Source sequence(s)
      AF303831, BB200972, BE686521
      Consensus CDS
      CCDS25811.1
      UniProtKB/Swiss-Prot
      Q9ERI6
      UniProtKB/TrEMBL
      Q569U9
      Related
      ENSMUSP00000020947.6, ENSMUST00000020947.7
      Conserved Domains (2) summary
      PRK06197
      Location:43 → 332
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:44 → 326
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      10440752..10445562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514943.5 → XP_006515006.1  retinol dehydrogenase 14 isoform X1

      UniProtKB/TrEMBL
      Q569U9
      Conserved Domains (1) summary
      cl21454
      Location:3 → 285
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERI6.1 GenPept UniProtKB/Swiss-Prot:Q9ERI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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