Syt4 synaptotagmin IV [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt4provided by MGI
Official Full Name: synaptotagmin IVprovided by MGI
Primary source: MGI:MGI:101759
See related: Ensembl:ENSMUSG00000024261 AllianceGenome:MGI:101759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SytIV
Summary: The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]
Expression: Biased expression in CNS E18 (RPKM 40.3), cerebellum adult (RPKM 32.9) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 17.75 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (31570861..31580468, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (31437808..31447415, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exocytosis in mouse vestibular Type II hair cells shows a high-order Ca(2+) dependence that is independent of synaptotagmin-4.
Title: Exocytosis in mouse vestibular Type II hair cells shows a high-order Ca(2+) dependence that is independent of synaptotagmin-4.
Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca(2+) influx via TRPM1 channels.
Title: Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca(2+) influx via TRPM1 channels.
Syt4 Overexpression Represses Basal Insulin Secretion and Impairs Islet Morphogenesis.
Title: Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca(2+) Sensitivity of Insulin Secretion Vesicles.
BDNF secretion mediated by syt-IV is subject to extensive temporal and spatial control to modulate the spatial pattern of synaptic efficacy in networks of neurons
Title: Distinct subsets of Syt-IV/BDNF vesicles are sorted to axons versus dendrites and recruited to synapses by activity.
Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels.
Title: Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels.
these data suggest that syt IV plays a role both in the Golgi and in the maintenance of normal numbers of synaptic vesicles in presynaptic terminals
Title: Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons.
From the results of this study the author proposed that the differential expression of synaptotagmins determines the characteristic Ca2+ sensitivity of vesicle fusion at hair cell synapses.
Title: Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.
Thus, regulation of BDNF secretion by syt-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP.
Title: Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release.
Given the neuroendocrine functions of the posterior pituitary, changes in Syt IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin
Title: Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals.
propose that Syt IV is essential for the regulated release of glutamate from astrocytes and is a candidate Ca2+ sensor for gliotransmission by these nonneuronal cells
Title: Synaptotagmin IV regulates glial glutamate release.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Syt4 (e-PCR), detects polymorphism
- UniSTS:465500

U10355 (e-PCR)
- UniSTS:181109

Syt4 (e-PCR), detects polymorphism
- UniSTS:507263

NoName (e-PCR)
- UniSTS:224647

NoName (e-PCR)
- UniSTS:237759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-1 binding	IEA Inferred from Electronic Annotation more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info
enables syntaxin-3 binding	IEA Inferred from Electronic Annotation more info
enables syntaxin-3 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dense core granule cytoskeletal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dense core granule cytoskeletal transport	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catecholamine secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catecholamine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dense core granule exocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dense core granule exocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of retrograde trans-synaptic signaling by neuropeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendrite extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic dense core vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic dense core vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle fusion	ISO Inferred from Sequence Orthology more info
involved_in secretory granule maturation	IEA Inferred from Electronic Annotation more info
involved_in secretory granule maturation	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle transport	TAS Traceable Author Statement more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion with vesicle	IEA Inferred from Electronic Annotation more info
involved_in vesicle fusion with vesicle	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in microvesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuronal dense core vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed
located_in neuronal dense core vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	NAS Non-traceable Author Statement more info	PubMed
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptotagmin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009308.3 → NP_033334.2 synaptotagmin-4

See identical proteins and their annotated locations for NP_033334.2

Status: REVIEWED

Source sequence(s)

AK032106, CAAA01195961, CN666882

Consensus CDS

CCDS29109.1

UniProtKB/Swiss-Prot

P40749, Q3UFC1, Q8BGH3, Q8BRL6

UniProtKB/TrEMBL

Q571C5

Related

ENSMUSP00000025110.4, ENSMUST00000025110.5

Conserved Domains (2) summary

cd08388
Location:153 → 279

C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11

cd08404
Location:288 → 423

C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

31570861..31580468 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317852.3 → XP_017173341.1 synaptotagmin-4 isoform X1

Conserved Domains (2) summary

cd08404
Location:106 → 241

C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

cl14603
Location:1 → 97

C2; C2 domain