U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Arhgef38 Rho guanine nucleotide exchange factor 38 [ Mus musculus (house mouse) ]

    Gene ID: 77669, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Arhgef38provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 38provided by MGI
    Primary source
    MGI:MGI:1924919
    See related
    Ensembl:ENSMUSG00000040969 AllianceGenome:MGI:1924919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130221D24Rik; D630013G24Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Orthologous to human ARHGEF38 (Rho guanine nucleotide exchange factor 38). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Arhgef38 in Genome Data Viewer
    Location:
    3 G3; 3 61.57 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132818039..132940710, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (133112278..133234949, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, C-terminal domain containing Neighboring gene TIP41, TOR signalling pathway regulator-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6130 Neighboring gene STARR-positive B cell enhancer ABC_E9573 Neighboring gene STARR-positive B cell enhancer mm9_chr3:132754721-132755022 Neighboring gene STARR-positive B cell enhancer ABC_E11218 Neighboring gene integrator complex subunit 12 Neighboring gene STARR-seq mESC enhancer starr_09022 Neighboring gene predicted gene, 52616 Neighboring gene STARR-positive B cell enhancer ABC_E10215 Neighboring gene STARR-positive B cell enhancer ABC_E4594 Neighboring gene STARR-positive B cell enhancer ABC_E4595 Neighboring gene STARR-positive B cell enhancer ABC_E9574 Neighboring gene STARR-seq mESC enhancer starr_09023 Neighboring gene pyrophosphatase (inorganic) 2 Neighboring gene STARR-seq mESC enhancer starr_09025 Neighboring gene STARR-seq mESC enhancer starr_09033 Neighboring gene tet methylcytosine dioxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_09034 Neighboring gene STARR-positive B cell enhancer ABC_E6131

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC54810

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rho guanine nucleotide exchange factor 38
    Names
    Rho guanine nucleotide exchange factor (GEF) 38
    putative Rho guanine nucleotide exchange factor FLJ20184 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368752.1 → NP_001355681.1  rho guanine nucleotide exchange factor 38 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124593, AC124605, AEKQ02022826
      Consensus CDS
      CCDS89690.1
      UniProtKB/Swiss-Prot
      E2QRQ2, Q80VK6, Q9D274
      Related
      ENSMUSP00000114238.4, ENSMUST00000147041.10
      Conserved Domains (4) summary
      cd07589
      Location:336 → 510
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd12141
      Location:710 → 766
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      pfam00621
      Location:98 → 283
      RhoGEF; RhoGEF domain
      cl17036
      Location:585 → 641
      SH3; Src Homology 3 domain superfamily

    2. NM_029953.1 → NP_084229.1  rho guanine nucleotide exchange factor 38 isoform 2

      See identical proteins and their annotated locations for NP_084229.1

      Status: VALIDATED

      Source sequence(s)
      BC049886
      Consensus CDS
      CCDS17849.1
      UniProtKB/Swiss-Prot
      Q80VK6
      Related
      ENSMUSP00000124280.3, ENSMUST00000161022.9
      Conserved Domains (1) summary
      cl02571
      Location:98 → 217
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      132818039..132940710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VK6.2 GenPept UniProtKB/Swiss-Prot:Q80VK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous