Itga11 integrin alpha 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga11provided by MGI
Official Full Name: integrin alpha 11provided by MGI
Primary source: MGI:MGI:2442114
See related: Ensembl:ENSMUSG00000032243 AllianceGenome:MGI:2442114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4732459H24Rik
Summary: Predicted to enable collagen binding activity involved in cell-matrix adhesion; collagen receptor activity; and integrin binding activity. Acts upstream of or within fibroblast migration and substrate-dependent cell migration. Predicted to be located in focal adhesion. Predicted to be part of integrin alpha11-beta1 complex. Predicted to be active in external side of plasma membrane. Is expressed in brain meninges; limb; skeleton; tail paraxial mesenchyme; and thymus primordium. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ITGA11 (integrin subunit alpha 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 7.7), bladder adult (RPKM 6.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.82 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (62585137..62691618)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (62677855..62783979)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
Title: PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis.
Title: Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis.
Integrin alpha11beta1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart.
Title: Integrin α11β1 and syndecan-4 dual receptor ablation attenuate cardiac hypertrophy in the pressure overloaded heart.
integrin alpha11 pro-invasive activity relies on its ability to interact with PDGFRbeta in a ligand-dependent manner and to promote its downstream JNK activation, leading to the production of tenascin C, a pro-invasive matricellular protein.
Title: Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.
Data show that integrin alpha-11 (integrin alpha11) is a physiologically important receptor for Osteolectin, mediating its effect on osteogenesis.
Title: Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.
We report for the first time that overexpression of integrin alpha11 induces cardiac fibrosis and left ventricular hypertrophy
Title: Overexpression of integrin α11 induces cardiac fibrosis in mice.
Data show that stromal integrin alpha11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft indicating a new role for integrin alpha11beta1 in the tumor microenvironment. These results suggest that integrin alpha11beta1 has a pro-tumorigenic effect on triple-negative breast cancer growth in vivo.
Title: Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors.
Deletion of ITGA11 in diabetic mice attenuates cardiac fibrosis progression but does not improve cardiac function. Impairments of cardiac function in null mice appear to be due to a novel role of ITGA11 in regulating cardiomyocyte growth and organization and myofibril development.
Title: The α11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease.
In NSCLC xenografts in Itga11-knockout mice, collagen cross-linking is associated with stromal alpha11 expression. Loss of tumor stromal alpha11 expression was correlated with decreased collagen reorganization and stiffness.
Title: Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer.
Deficiency of stromal integrin alpha11beta1 showed different effects on tumor growth and collagen fibril diameter depending on tumor type, but no effect on tumor interstitial fluid pressure or development of lung metastasis.
Title: Stromal Integrin α11β1 Affects RM11 Prostate and 4T1 Breast Xenograft Tumors Differently.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
enables collagen receptor activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in collagen-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate-dependent cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
part_of integrin alpha11-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-11

Names: integrin a11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176922.6 → NP_795896.4 integrin alpha-11 precursor

See identical proteins and their annotated locations for NP_795896.4

Status: VALIDATED

Source sequence(s)

AC164614, AC166097

Consensus CDS

CCDS23265.1

UniProtKB/Swiss-Prot

P61622

UniProtKB/TrEMBL

A0A0B4J1F0, Q7TQC3

Related

ENSMUSP00000034774.9, ENSMUST00000034774.9

Conserved Domains (3) summary

smart00191
Location:538 → 592

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:163 → 341

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:635 → 1034

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

62585137..62691618

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155048.1 → XP_036010941.1 integrin alpha-11 isoform X1

UniProtKB/Swiss-Prot

P61622

UniProtKB/TrEMBL

Q7TQC3

Conserved Domains (3) summary

smart00191
Location:514 → 568

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:139 → 317

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:611 → 1010

Integrin_alpha2; Integrin alpha