Ces1b carboxylesterase 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ces1bprovided by MGI
Official Full Name: carboxylesterase 1Bprovided by MGI
Primary source: MGI:MGI:3779470
See related: Ensembl:ENSMUSG00000078964 AllianceGenome:MGI:3779470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm5158
Summary: Predicted to enable carboxylesterase activity; protein homodimerization activity; and sterol ester esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver adult (RPKM 70.0) See more
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Genomic context

Location:: 8 C5; 8 44.99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (93783353..93806645, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (93056725..93080017, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxylesterase 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081372.1 → NP_001074841.1 carboxylesterase 1B isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC121985

Consensus CDS

CCDS40431.1

UniProtKB/TrEMBL

D3Z5G7

Related

ENSMUSP00000105210.2, ENSMUST00000109582.3

Conserved Domains (2) summary

COG0657
Location:121 → 239

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:19 → 547

COesterase; Carboxylesterase family
NM_001381922.1 → NP_001368851.1 carboxylesterase 1B isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC121985

Conserved Domains (1) summary

pfam00135
Location:22 → 532

COesterase; Carboxylesterase family