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    Kcng2 potassium voltage-gated channel, subfamily G, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 240444, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcng2provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily G, member 2provided by MGI
    Primary source
    MGI:MGI:3694646
    See related
    Ensembl:ENSMUSG00000059852 AllianceGenome:MGI:3694646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG2 (potassium voltage-gated channel modifier subfamily G member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 41.8) and thymus adult (RPKM 2.3) See more
    Orthologs
    human all
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    Genomic context

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    See Kcng2 in Genome Data Viewer
    Location:
    18 E3; 18 53.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80337731..80407469, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80294544..80364254, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_45175 Neighboring gene solute carrier family 66 member 2 Neighboring gene VISTA enhancer mm152 Neighboring gene predicted gene, 26676 Neighboring gene RIKEN cDNA D330025C20 gene Neighboring gene predicted gene, 29967 Neighboring gene STARR-seq mESC enhancer starr_45177 Neighboring gene CTD phosphatase subunit 1 Neighboring gene predicted gene 9456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily G member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190373.1 → NP_001177302.1  potassium voltage-gated channel subfamily G member 2

      See identical proteins and their annotated locations for NP_001177302.1

      Status: VALIDATED

      Source sequence(s)
      AC145610
      Consensus CDS
      CCDS57127.1
      UniProtKB/TrEMBL
      F7A6P6
      Related
      ENSMUSP00000077112.7, ENSMUST00000077962.8
      Conserved Domains (2) summary
      cl38908
      Location:33 → 127
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein

    2. NM_001404104.1 → NP_001391033.1  potassium voltage-gated channel subfamily G member 2

      Status: VALIDATED

      Source sequence(s)
      AC145610
      UniProtKB/TrEMBL
      F7A6P6

    3. NM_001404105.1 → NP_001391034.1  potassium voltage-gated channel subfamily G member 2

      Status: VALIDATED

      Source sequence(s)
      AC145610
      UniProtKB/TrEMBL
      F7A6P6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      80337731..80407469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317904.3 → XP_017173393.1  potassium voltage-gated channel subfamily G member 2 isoform X1

      UniProtKB/TrEMBL
      F7A6P6
      Conserved Domains (2) summary
      cl38908
      Location:33 → 127
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:190 → 429
      Ion_trans; Ion transport protein
    Nucleotide Protein Strain
    Heading Accession and Version

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