Gm12185 predicted gene 12185 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gm12185provided by MGI
Official Full Name: predicted gene 12185provided by MGI
Primary source: MGI:MGI:3652173
See related: Ensembl:ENSMUSG00000048852 AllianceGenome:MGI:3652173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Irgb2b1
Summary: Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 11 B1.2; 11 28.89 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (48795483..48818009, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (48904656..48927182, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that Irgb2-b1CIM is the CIM mice-inherited element largely responsible for resistance against virulent Eurasian T. gondii strains and demonstrate efficient binding of Irgb2-b1CIM only to virulent T. gondii-derived ROP5B but not ROP5A and ROP5C.
Title: Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice.

Submit: New GeneRIF Correction

General gene information

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Markers

48.MMHAP86FRH12.seq (e-PCR)
- UniSTS:124705

33.MHAa63c9.seq (e-PCR)
- UniSTS:124017

UniSTS:479190 (e-PCR)
- UniSTS:479190

Pcbp2 (e-PCR), detects polymorphism
- UniSTS:479190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon inducible GTPase

Names: Immunity related GTPase, B2-B1 tandem, WSB specific

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045540.2 → NP_001039005.1 interferon inducible GTPase

See identical proteins and their annotated locations for NP_001039005.1

Status: VALIDATED

Source sequence(s)

AL645849

Consensus CDS

CCDS36142.1

UniProtKB/TrEMBL

A0A1G5SJB0, Q5NCB2

Related

ENSMUSP00000092049.3, ENSMUST00000094476.9

Conserved Domains (3) summary

cd04104
Location:472 → 668

p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1

pfam05049
Location:438 → 810

IIGP; Interferon-inducible GTPase (IIGP)

cl21455
Location:61 → 257

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases