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    Zfp386 zinc finger protein 386 (Kruppel-like) [ Mus musculus (house mouse) ]

    Gene ID: 56220, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp386provided by MGI
    Official Full Name
    zinc finger protein 386 (Kruppel-like)provided by MGI
    Primary source
    MGI:MGI:1930708
    See related
    Ensembl:ENSMUSG00000042063 AllianceGenome:MGI:1930708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kzf1; mKIAA4205
    Summary
    Enables chromatin binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; neural retina; and olfactory epithelium. Orthologous to human ZNF519 (zinc finger protein 519). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.4) and 25 other tissues See more
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    Genomic context

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    See Zfp386 in Genome Data Viewer
    Location:
    12 F2; 12 62.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116011334..116026851)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116047714..116063231)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy chain complex Neighboring gene STARR-positive B cell enhancer ABC_E923 Neighboring gene immunoglobulin heavy variable 1-85 Neighboring gene immunoglobulin heavy variable 1-86 Neighboring gene predicted gene, 53772 Neighboring gene predicted gene, 46383 Neighboring gene vasoactive intestinal peptide receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
    2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4205

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 386 (Kruppel-like)
    Names
    Kruppel associated box (KRAB) zinc finger 1
    kruppel-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004066.3 → NP_001004066.1  zinc finger protein 386 (Kruppel-like) isoform a

      See identical proteins and their annotated locations for NP_001004066.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC243430, CF723896, CJ140586
      Consensus CDS
      CCDS26209.1
      UniProtKB/TrEMBL
      Q1WWJ5
      Related
      ENSMUSP00000138305.2, ENSMUST00000183125.2
      Conserved Domains (5) summary
      smart00349
      Location:6 → 46
      KRAB; krueppel associated box
      COG5048
      Location:461 → 621
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:465 → 485
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:533 → 558
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001286214.1 → NP_001273143.1  zinc finger protein 386 (Kruppel-like) isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the coding region, which results in a reading frame shift, compared to variant 1. The resulting isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC243430, BE652367, CJ140586
      Conserved Domains (1) summary
      pfam01352
      Location:5 → 36
      KRAB; KRAB box

    3. NM_019565.4 → NP_062511.2  zinc finger protein 386 (Kruppel-like) isoform b

      See identical proteins and their annotated locations for NP_062511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC243430, AK165544, CJ140586
      Consensus CDS
      CCDS59580.1
      UniProtKB/TrEMBL
      Q3TN43
      Related
      ENSMUSP00000073241.6, ENSMUST00000073551.6
      Conserved Domains (5) summary
      smart00349
      Location:6 → 45
      KRAB; krueppel associated box
      COG5048
      Location:426 → 586
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:498 → 523
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      116011334..116026851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157539.1 → XP_036013432.1  zinc finger protein 386 (Kruppel-like) isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:392 → 552
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:396 → 416
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:352 → 377
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011244150.3 → XP_011242452.1  zinc finger protein 386 (Kruppel-like) isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:189 → 349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:149 → 174
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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