Ncapd2 non-SMC condensin I complex, subunit D2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncapd2provided by MGI
Official Full Name: non-SMC condensin I complex, subunit D2provided by MGI
Primary source: MGI:MGI:1915548
See related: Ensembl:ENSMUSG00000038252 AllianceGenome:MGI:1915548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CNAP1; CAP-D2; mKIAA0159; 2810406C15Rik; 2810465G24Rik
Summary: Predicted to enable histone binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Located in condensed nuclear chromosome and pronucleus. Part of condensin complex. Is expressed in several structures, including central nervous system; retina outer nuclear layer; and salivary gland. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 53.3), thymus adult (RPKM 40.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2- F3; 6 59.32 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (125144970..125169062, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (125168007..125192100, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCAPD2 inhibits autophagy by regulating Ca(2+)/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer.
Title: NCAPD2 inhibits autophagy by regulating Ca(2+)/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer.
Condensins I and II have overlapping and non-overlapping functions in Neural stem cells.
Title: Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions.
Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Igkappa Vkappa genes suggesting a direct role for YY1-condensin complexes in Igkappa locus structure and rearrangement.
Title: YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus.
Data show that that DNA repear process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.
Title: Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.
The characterization of two novel E2F target genes, chromosome condensation-related SMC-associated protein 1 (Cnap1) and maternal embryonic leucine zipper kinase (Melk) is reported.
Title: Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in meiotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome condensation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
is_active_in condensed chromosome, centromeric region	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	IDA Inferred from Direct Assay more info	PubMed
part_of condensin complex	ISO Inferred from Sequence Orthology more info
part_of condensin complex	NAS Non-traceable Author Statement more info	PubMed
part_of condensin complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: condensin complex subunit 1

Names: XCAP-D2 homolog; chromosome condensation-related SMC-associated protein 1; chromosome-associated protein D2; mCAP-D2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417657.1 → NP_001404586.1 condensin complex subunit 1

Status: VALIDATED

Source sequence(s)

AC166162

UniProtKB/TrEMBL

A0A0R4J0H7
NM_146171.2 → NP_666283.1 condensin complex subunit 1

See identical proteins and their annotated locations for NP_666283.1

Status: VALIDATED

Source sequence(s)

AC166162

Consensus CDS

CCDS39636.1

UniProtKB/Swiss-Prot

Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32

UniProtKB/TrEMBL

A0A0R4J0H7

Related

ENSMUSP00000042260.5, ENSMUST00000043848.11

Conserved Domains (2) summary

COG5098
Location:185 → 1235

COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]

pfam12922
Location:75 → 240

Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

125144970..125169062 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506532.4 → XP_006506595.1 condensin complex subunit 1 isoform X2

UniProtKB/Swiss-Prot

Q6ZQI1, Q8K2Z4, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32

Conserved Domains (2) summary

COG5098
Location:67 → 1117

COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]

pfam12922
Location:1 → 122

Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
XM_006506533.4 → XP_006506596.1 condensin complex subunit 1 isoform X3

Conserved Domains (2) summary

COG5098
Location:185 → 728

COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]

pfam12922
Location:75 → 240

Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term