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    Zfp811 zinc finger protein 811 [ Mus musculus (house mouse) ]

    Gene ID: 240063, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp811provided by MGI
    Official Full Name
    zinc finger protein 811provided by MGI
    Primary source
    MGI:MGI:2682944
    See related
    Ensembl:ENSMUSG00000055202 AllianceGenome:MGI:2682944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in gut; nervous system; and neural retina. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 8.3), CNS E14 (RPKM 8.0) and 7 other tissues See more
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    Genomic context

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    See Zfp811 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33014650..33029033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32795676..32810057, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 871 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32925111-32925412 Neighboring gene predicted gene 17115 Neighboring gene predicted gene, 23294 Neighboring gene zinc finger protein 799 Neighboring gene zinc finger protein 458 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC62423

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 811

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267583.1 → NP_001254512.1  zinc finger protein 811 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' region, which results in an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AI413693, AK132056, BM951801, CT485613
      Consensus CDS
      CCDS89068.1
      UniProtKB/TrEMBL
      A0A3Q4EGT7
      Related
      ENSMUSP00000157159.2, ENSMUST00000234594.2
      Conserved Domains (2) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 43
      KRAB; KRAB box

    2. NM_183177.3 → NP_899000.2  zinc finger protein 811 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI413693, AK132056, BC052046, CT485613
      Consensus CDS
      CCDS79528.1
      UniProtKB/TrEMBL
      A0A0J9YU71
      Related
      ENSMUSP00000144038.2, ENSMUST00000200914.5
      Conserved Domains (5) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      COG5048
      Location:217 → 547
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:279 → 299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:319 → 344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33014650..33029033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317470.3 → XP_017172959.1  zinc finger protein 811 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:208 → 357
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 30
      KRAB; KRAB box

    2. XM_030249792.2 → XP_030105652.1  zinc finger protein 811 isoform X1

      Related
      ENSMUSP00000079709.7, ENSMUST00000080905.7
      Conserved Domains (3) summary
      COG5048
      Location:208 → 357
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 30
      KRAB; KRAB box

    3. XM_011246439.3 → XP_011244741.1  zinc finger protein 811 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:206 → 355
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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