Tlr13 toll-like receptor 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr13provided by MGI
Official Full Name: toll-like receptor 13provided by MGI
Primary source: MGI:MGI:3045213
See related: Ensembl:ENSMUSG00000033777 AllianceGenome:MGI:3045213
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm713
Summary: Enables identical protein binding activity and rRNA binding activity. Involved in innate immune response and toll-like receptor 13 signaling pathway. Acts upstream of or within MyD88-dependent toll-like receptor signaling pathway; regulation of MAPK cascade; and response to virus. Located in endosome. Is expressed in vibrissa. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X D; X 47.36 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (105186881..105204099)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (106143275..106160493)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease.
Title: TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease.
Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci.
Title: Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci.
Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA has been presented.
Title: Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA.
S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 and subsequently by TLR13 upon internalization.
Title: Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.
TLR13 expressed by immune cells detects bacterial RNA with exquisite sequence specificity.
Title: Sequence specific detection of bacterial 23S ribosomal RNA by TLR13.
These data lend support to the conclusion that TLR13 participates in group B streptococcus recognition, although blockade of the function of this receptor can be compensated for by other endosomal toll-like receptors.
Title: Role of Toll-like receptor 13 in innate immune recognition of group B streptococci.
TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA.
Title: Cutting edge: TLR13 is a receptor for bacterial RNA.
these results show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably
Title: TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.
the potential role of the novel Toll-like receptor tlr13 in the recognition of viral infection.
Title: A novel Toll-like receptor that recognizes vesicular stomatitis virus.
These findings reveal the mechanism of Tlr13 gene regulation, thereby providing insight into the function of Tlr13 in the immune response to pathogen.
Title: Transcriptional regulation of the novel Toll-like receptor Tlr13.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within MyD88-dependent toll-like receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 13 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 13

NP_991389.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205820.1 → NP_991389.1 toll-like receptor 13 precursor

See identical proteins and their annotated locations for NP_991389.1

Status: PROVISIONAL

Source sequence(s)

AY510706

Consensus CDS

CCDS30338.1

UniProtKB/Swiss-Prot

Q148Y7, Q3TDS2, Q6R5N8

Related

ENSMUSP00000043101.4, ENSMUST00000040065.4

Conserved Domains (5) summary

smart00255
Location:834 → 976

TIR; Toll - interleukin 1 - resistance

cd00116
Location:192 → 405

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:373 → 397

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:420 → 463

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:492 → 552

LRR_8; Leucine rich repeat