Pon1 paraoxonase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pon1provided by MGI
Official Full Name: paraoxonase 1provided by MGI
Primary source: MGI:MGI:103295
See related: Ensembl:ENSMUSG00000002588 AllianceGenome:MGI:103295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pon
Summary: Enables arylesterase activity. Acts upstream of or within cholesterol metabolic process and response to toxic substance. Predicted to be part of spherical high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 147.4), liver E18 (RPKM 50.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (5168101..5193824, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (5168090..5193987, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice.
Title: Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice.
Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
Title: Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet.
Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
Title: Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.
Ccl2 gene ablation protects LDL receptor and PON1 double deficient mice from liver injury, oxidative stress and inflammation.
Title: Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
Study shows that PON1 can significantly relieve airway inflammation and airway remolding in asthma mice, and inhibit the secretion of LPS induced macrophage inflammatory cytokines and the proliferation of lung fibroblasts. These results suggest that PON1 may be involved in airway inflammation and remodeling in asthma.
Title: Influences of PON1 on airway inflammation and remodeling in bronchial asthma.
PON1 overexpression protects against AAA progression by reducing oxidative stress, apoptosis and inflammation
Title: Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression.
Paraoxonase 1 (PON1) influence circadian gene expression and period length
Title: Paraoxonase 1 (PON1) and pomegranate influence circadian gene expression and period length.
results suggest that Hyperhomocysteinemia plays an intricate role in dysfunctional HDL, owing to the lack of PON1. This contributes to vascular endothelial impairment and atherosclerosis.
Title: Hyperhomocysteinemia: a missing link to dysfunctional HDL via paraoxanase-1.
Maternal PON1 status modulates the effects of repeated gestational chlorpyrifos oxon exposure on fetal-brain gene expression and on inhibition of both maternal and fetal biomarker enzymes.
Title: Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues.
5,6-dihydroxyeicosatrienoate-1,5-lactone, a stable metabolite of arachidonic acid, is a potential substrate for PON1.
Title: 5,6-δ-DHTL, a stable metabolite of arachidonic acid, is a potential substrate for paraoxonase 1.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

U32684 (e-PCR)
- UniSTS:125724

Pon1 (e-PCR), detects polymorphism
- UniSTS:273727

Pon1 (e-PCR), detects polymorphism
- UniSTS:144236

Pon1 (e-PCR), detects polymorphism
- UniSTS:144237

Pon1 (e-PCR), detects polymorphism
- UniSTS:144238

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-L-homoserine-lactone lactonohydrolase activity	IEA Inferred from Electronic Annotation more info
enables acyl-L-homoserine-lactone lactonohydrolase activity	ISO Inferred from Sequence Orthology more info
enables aryldialkylphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aryldialkylphosphatase activity	ISO Inferred from Sequence Orthology more info
enables aryldialkylphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables arylesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables high-density lipoprotein particle binding	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood circulation	TAS Traceable Author Statement more info	PubMed
involved_in carboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in lactone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in organophosphate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in organophosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in response to fluoride	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serum paraoxonase/arylesterase 1

Names: A-esterase 1; PON 1; aromatic esterase 1; serum aryldialkylphosphatase 1

NP_001397188.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NP_001397189.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NP_001397190.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NP_035264.2

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410259.1 → NP_001397188.1 serum paraoxonase/arylesterase 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC074225
NM_001410260.1 → NP_001397189.1 serum paraoxonase/arylesterase 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC074225

Related

ENSMUSP00000135195.3, ENSMUST00000177159.9
NM_001410261.1 → NP_001397190.1 serum paraoxonase/arylesterase 1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC074225
NM_011134.4 → NP_035264.2 serum paraoxonase/arylesterase 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_035264.2

Status: VALIDATED

Source sequence(s)

AC074225

Consensus CDS

CCDS19898.1

UniProtKB/Swiss-Prot

P52430, Q91X30

Related

ENSMUSP00000002663.6, ENSMUST00000002663.12

Conserved Domains (1) summary

pfam01731
Location:168 → 253

Arylesterase; Arylesterase