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    Ppfia3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 76787, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ppfia3provided by MGI
    Official Full Name
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3provided by MGI
    Primary source
    MGI:MGI:1924037
    See related
    Ensembl:ENSMUSG00000003863 AllianceGenome:MGI:1924037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410127E16Rik
    Summary
    Involved in synaptic vesicle docking. Located in acrosomal vesicle. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Is expressed in nervous system; nose; and retina layer. Orthologous to human PPFIA3 (PTPRF interacting protein alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 33.6), frontal lobe adult (RPKM 25.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppfia3 in Genome Data Viewer
    Location:
    7 B3; 7 29.26 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44988550..45016443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45339126..45367019, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 4 Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene histidine rich calcium binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2237 Neighboring gene STARR-positive B cell enhancer ABC_E700 Neighboring gene STARR-positive B cell enhancer ABC_E11352 Neighboring gene metastasis associated gene 2 Neighboring gene lin-7 homolog B, crumbs cell polarity complex component Neighboring gene small nuclear ribonucleoprotein 70 (U1)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function. Brenig J, et al. J Biol Chem, 2015 Jun 5. PMID 25911102, Free PMC Article
    2. Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α. Wakita M, et al. Nat Commun, 2020 Jan 31. PMID 32005855, Free PMC Article
    3. Liprin α3: a putative estrogen regulated acrosomal protein. Joshi CS, et al. Histochem Cell Biol, 2013 Apr. PMID 23124857
    4. PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure. Emperador-Melero J, et al. Nat Commun, 2021 May 24. PMID 34031393, Free PMC Article
    5. The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Zürner M, et al. Genomics, 2009 Mar. PMID 19013515

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKC-phosphorylation of Liprin-alpha3 triggers phase separation and controls presynaptic active zone structure.
      Title: PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.
    2. PTPdelta D2 interacts with the N-terminal helix and the first and second SAMs (SAM1 and SAM2, respectively) of Liprin-alpha3.
      Title: Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α.
    3. Liprin-alpha3 has important roles in active-zone assembly and function; interplay between various Liprin-alpha proteins controls their active-zone localization
      Title: Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses.
    4. Liprin-alpha3 uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 activation by RhoA.
      Title: Structural and Biochemical Basis for the Inhibitory Effect of Liprin-α3 on Mouse Diaphanous 1 (mDia1) Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of short-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of short-term neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle docking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in epididymosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in epididymosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    liprin-alpha-3
    Names
    Liprin-alpha3
    PTPRF-interacting protein alpha-3
    protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029741.2 → NP_084017.2  liprin-alpha-3

      See identical proteins and their annotated locations for NP_084017.2

      Status: VALIDATED

      Source sequence(s)
      AK010782, AK147645, AW060329, BC058404
      Consensus CDS
      CCDS52246.1
      UniProtKB/Swiss-Prot
      B8QI35, P60469
      UniProtKB/TrEMBL
      C7G3P1
      Related
      ENSMUSP00000003961.9, ENSMUST00000003961.16
      Conserved Domains (5) summary
      cd09562
      Location:835 → 905
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:952 → 1017
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1037 → 1108
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:151 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28929
      Location:535 → 747
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44988550..45016443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250914.2 → XP_011249216.1  liprin-alpha-3 isoform X2

      UniProtKB/TrEMBL
      C7G3P1
      Conserved Domains (5) summary
      cd09562
      Location:835 → 905
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:943 → 1008
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1028 → 1099
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:151 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28929
      Location:535 → 747
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    2. XM_036153552.1 → XP_036009445.1  liprin-alpha-3 isoform X2

      UniProtKB/TrEMBL
      C7G3P1
      Related
      ENSMUSP00000147584.2, ENSMUST00000210248.2
      Conserved Domains (5) summary
      cd09562
      Location:835 → 905
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:943 → 1008
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1028 → 1099
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:151 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28929
      Location:535 → 747
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    3. XM_006541273.2 → XP_006541336.1  liprin-alpha-3 isoform X1

      See identical proteins and their annotated locations for XP_006541336.1

      UniProtKB/Swiss-Prot
      B8QI35, P60469
      UniProtKB/TrEMBL
      C7G3P1
      Related
      ENSMUST00000210586.2
      Conserved Domains (5) summary
      cd09562
      Location:835 → 905
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:952 → 1017
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1037 → 1108
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:151 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28929
      Location:535 → 747
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    4. XM_036153551.1 → XP_036009444.1  liprin-alpha-3 isoform X1

      UniProtKB/Swiss-Prot
      B8QI35, P60469
      UniProtKB/TrEMBL
      C7G3P1
      Related
      ENSMUST00000210479.2
      Conserved Domains (5) summary
      cd09562
      Location:835 → 905
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:952 → 1017
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1037 → 1108
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:151 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28929
      Location:535 → 747
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    5. XM_011250912.4 → XP_011249214.1  liprin-alpha-3 isoform X1

      See identical proteins and their annotated locations for XP_011249214.1

      UniProtKB/Swiss-Prot
      B8QI35, P60469
      UniProtKB/TrEMBL
      C7G3P1
      Related
      ENSMUSP00000148200.2, ENSMUST00000211067.2
      Conserved Domains (5) summary
      cd09562
      Location:835 → 905
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:952 → 1017
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1037 → 1108
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:151 → 496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl28929
      Location:535 → 747
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    6. XM_011250915.4 → XP_011249217.1  liprin-alpha-3 isoform X3

      Conserved Domains (3) summary
      cd09562
      Location:284 → 354
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:401 → 466
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:486 → 557
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60469.2 GenPept UniProtKB/Swiss-Prot:P60469

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