SUVR2 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SUVR2
Official Full Name: SET-domain containing protein lysine methyltransferase family protein
Primary source: TAIR:AT5G43990
Locus tag: AT5G43990
See related: Araport:AT5G43990
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MRH10.10; MRH10_10; SDG18; SET DOMAIN PROTEIN 18
Summary: Encodes SUVR2, one of the four closely related Arabidopsis SUVR proteins that belong to the SU(VAR)3-9 subgroup of SET-domain proteins. Proteins containing the evolutionarily conserved SET domain are involved in regulation of eukaryotic gene expression and chromatin structure through their histone lysine methyltransferase (HMTase) activity. SUVR1, SUVR2 and SUVR4 proteins contain a novel domain at their N-terminus, and a SUVR specific region preceding the SET domain. Localized to the nucleolus, maybe involved in regulation of rRNA expression.
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Genomic context

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See SUVR2 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 10

Sequence:: Chromosome: 5; NC_003076.8 (17697686..17702036)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study suggests that the involvement of SUVR2 in transcriptional gene silencing is related to nucleosome positioning mediated by its associated chromatin-remodeling proteins.
Title: SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001085233.2

Supported by ESTs:

NM_001085234.2

Supported by ESTs:

NM_001203540.1

Supported by ESTs:

NM_001344513.1

Supported by ESTs:

NM_001344514.1

Supported by ESTs:

NM_001344515.1

Supported by ESTs:

NM_001344516.1

Supported by ESTs:

NM_001344517.1

Supported by ESTs:

NM_001344518.1

Supported by ESTs:

NM_001344519.1

Supported by ESTs:

NM_001344520.1

Supported by ESTs:

NM_001344521.1

Supported by ESTs:

NM_001344522.1

Supported by ESTs:

NM_001344523.1

Supported by ESTs:

NM_001344524.1

Supported by ESTs:

NM_123766.3

Supported by ESTs:

NM_203151.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gene silencing by siRNA-directed DNA methylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SET-domain containing protein lysine methyltransferase family protein

NP_001078702.1

SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 3185 Blast hits to 3003 proteins in 299 species: Archae - 0; Bacteria - 104; Metazoa - 1652; Fungi - 402; Plants - 762; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).

NP_001078703.1

SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 3185 Blast hits to 3003 proteins in 299 species: Archae - 0; Bacteria - 104; Metazoa - 1652; Fungi - 402; Plants - 762; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).

NP_001190469.1

SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1).

NP_568631.1

SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET zinc-binding sub-group (InterPro:IPR003606), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974880.1

SUVR2; FUNCTIONS IN: zinc ion binding, histone-lysine N-methyltransferase activity; INVOLVED IN: chromatin modification; LOCATED IN: nucleolus, chloroplast; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), WIYLD domain (InterPro:IPR018848), Pre-SET domain (InterPro:IPR007728); BEST Arabidopsis thaliana protein match is: homolog of SU(var)3-9 1 (TAIR:AT1G04050.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

17697686..17702036

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203540.1 → NP_001190469.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FDG4, F4K7E7

Conserved Domains (3) summary

smart00317
Location:530 → 665

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:376 → 522

Pre-SET; Pre-SET motif

pfam10440
Location:6 → 59

WIYLD; Ubiquitin-binding WIYLD domain
NM_001344521.1 → NP_001331765.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178URU9, A0A1P8BEV9
NM_001344522.1 → NP_001331764.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UPJ7, A0A1P8BEV2
NM_001344524.1 → NP_001331762.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UR43, F4K7E3
NM_001344513.1 → NP_001331768.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BEV8, A0A7G2FDG4
NM_001344514.1 → NP_001331767.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WKU5, Q941L4, Q9FNC7

UniProtKB/TrEMBL

A0A178UR43
NM_001344523.1 → NP_001331763.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178URU9, A0A1P8BEV9
NM_001085234.2 → NP_001078703.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WKU5, Q941L4, Q9FNC7

UniProtKB/TrEMBL

A0A178UR43

Conserved Domains (3) summary

smart00317
Location:550 → 685

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:396 → 542

Pre-SET; Pre-SET motif

pfam10440
Location:6 → 59

WIYLD; Ubiquitin-binding WIYLD domain
NM_123766.3 → NP_568631.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WKU5, Q941L4, Q9FNC7

UniProtKB/TrEMBL

A0A178UR43

Conserved Domains (3) summary

smart00317
Location:550 → 685

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:396 → 542

Pre-SET; Pre-SET motif

pfam10440
Location:6 → 59

WIYLD; Ubiquitin-binding WIYLD domain
NM_001344517.1 → NP_001331772.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FDG4, F4K7E7
NM_001344519.1 → NP_001331770.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FDG4, F4K7E7
NM_001344515.1 → NP_001331773.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178URU9, A0A1P8BEV9
NM_001344518.1 → NP_001331771.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BEV8, A0A7G2FDG4
NM_001344516.1 → NP_001331766.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178URU9, A0A1P8BEV9
NM_001344520.1 → NP_001331769.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2FDG4, F4K7E7
NM_001085233.2 → NP_001078702.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WKU5, Q941L4, Q9FNC7

UniProtKB/TrEMBL

A0A178UR43

Conserved Domains (3) summary

smart00317
Location:550 → 685

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:396 → 542

Pre-SET; Pre-SET motif

pfam10440
Location:6 → 59

WIYLD; Ubiquitin-binding WIYLD domain
NM_203151.3 → NP_974880.1 SET-domain containing protein lysine methyltransferase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UR43, F4K7E3

Conserved Domains (3) summary

smart00317
Location:573 → 708

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam05033
Location:419 → 565

Pre-SET; Pre-SET motif

pfam10440
Location:29 → 82

WIYLD; Ubiquitin-binding WIYLD domain