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    YPR1 trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YPR1
    Official Full Name
    trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1
    Primary source
    SGD:S000002776
    Locus tag
    YDR368W
    See related
    AllianceGenome:SGD:S000002776; FungiDB:YDR368W; VEuPathDB:YDR368W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldose reductase (NADPH) activity; carbonyl reductase (NADPH) activity; and diacetyl reductase ((S)-acetoin forming) (NAD+) activity. Involved in acetoin metabolic process; cellular response to oxidative stress; and pentose catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B) and AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YPR1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1213904..1214842)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mor1p Neighboring gene Kei1p Neighboring gene Xrs2p Neighboring gene Dxo1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Ypr1p from Saccharomyces cerevisiae as a 2-methylbutyraldehyde reductase. Ford G, et al. Yeast, 2002 Sep 15. PMID 12210903
    2. Amino acid sequence and characterization of aldo-keto reductase from bakers' yeast. Nakamura K, et al. Biosci Biotechnol Biochem, 1997 Feb. PMID 9058981
    3. Aldo-keto reductase enzymes detoxify glyphosate and improve herbicide resistance in plants. Vemanna RS, et al. Plant Biotechnol J, 2017 Jul. PMID 27611904, Free PMC Article
    4. Highly stereoselective reagents for beta-keto ester reductions by genetic engineering of baker's yeast. Rodríguez S, et al. J Am Chem Soc, 2001 Feb 28. PMID 11456752
    5. Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway. Hwang JY, et al. Biotechnol Bioeng, 2009 Apr 1. PMID 19016485

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacetyl reductase ((S)-acetoin forming) (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetoin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arabinose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arabinose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arabinose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1
    NP_010656.1
    • NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1213904..1214842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180676.1 → NP_010656.1  TPA: trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSZ9, Q12458
      UniProtKB/TrEMBL
      B3LFT5, B5VGP8, C7GMG9, C8Z5S9, G2WBA4, N1PAI7
      Conserved Domains (1) summary
      cd19117
      Location:7 → 296
      AKR_AKR3A1-2; AKR3A family of aldo-keto reductase (AKR)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12458.1

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