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    SSN2 Ssn2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852053, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SSN2
    Official Full Name
    Ssn2p
    Primary source
    SGD:S000002851
    Locus tag
    YDR443C
    See related
    AllianceGenome:SGD:S000002851; FungiDB:YDR443C; VEuPathDB:YDR443C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED13; NUT8; RYE3; SCA1; SRB9; SSX5; UME2
    Summary
    Enables cyclin binding activity and transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of mediator complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and dextro-looped transposition of the great arteries. Orthologous to human MED13 (mediator complex subunit 13) and MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SSN2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1345676..1349938, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene histone methyltransferase DOT1 Neighboring gene adenine phosphoribosyltransferase APT2 Neighboring gene putative hydrolase Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [CaSRB9, a novel Candida albicans gene, plays a role in morphogenesis of Saccharomyces cerevisiae]. Zhou Z, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 May. PMID 12019441
    2. The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose. Surosky RT, et al. Mol Cell Biol, 1994 May. PMID 8164691, Free PMC Article
    3. Suppression analysis reveals a functional difference between the serines in positions two and five in the consensus sequence of the C-terminal domain of yeast RNA polymerase II. Yuryev A, et al. Genetics, 1996 Jun. PMID 8725217, Free PMC Article
    4. Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C. Khakhina S, et al. Mol Biol Cell, 2014 Sep 15. PMID 25057017, Free PMC Article
    5. Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation. Hanley SE, et al. Mol Biol Cell, 2024 Nov 1. PMID 39320938,

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Releasing cyclin C from the nucleus involves both its phosphorylation by Slt2p coupled with Med13p destruction.
      Title: Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C.
    2. Data show that two components of the RNA polymerase II machinery, Med13 (Srb9) and Spt8, are two-hybrid partners of the conserved TFIIS N-terminal domain.
      Title: Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ssn2p
    NP_010731.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1345676..1349938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180751.3 → NP_010731.3  TPA: Ssn2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010731.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT69, P38931
      UniProtKB/TrEMBL
      B3LFL7, N1P7I3
      Conserved Domains (2) summary
      pfam06333
      Location:1106 → 1385
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:8 → 279
      Med13_N; Mediator complex subunit 13 N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38931.2

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