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    SRPRA SRP receptor subunit alpha [ Homo sapiens (human) ]

    Gene ID: 6734, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SRPRAprovided by HGNC
    Official Full Name
    SRP receptor subunit alphaprovided by HGNC
    Primary source
    HGNC:HGNC:11307
    See related
    Ensembl:ENSG00000182934 MIM:182180; AllianceGenome:HGNC:11307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP; SRPR; Sralpha
    Summary
    The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 41.3), salivary gland (RPKM 33.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRPRA in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (126235930..126268895, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (126265417..126298379, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126132833..126138790, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA pseudouridine synthase D4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5703 Neighboring gene family with sequence similarity 118 member B Neighboring gene RNA, U4 small nuclear 86, pseudogene Neighboring gene MPRA-validated peak1502 silencer Neighboring gene MPRA-validated peak1503 silencer Neighboring gene RNA, 7SL, cytoplasmic 351, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5705 Neighboring gene FAD dependent oxidoreductase domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126147427-126147591 Neighboring gene ribosomal protein L35a pseudogene 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PCR-assisted localization of the human SRPR gene. Janin N, et al. Hum Genet, 1992 Mar. PMID 1312991
    2. The human docking protein does not associate with the membrane of the rough endoplasmic reticulum via a signal or insertion sequence-mediated mechanism. Hortsch M, et al. Biochem Biophys Res Commun, 1988 Jan 15. PMID 2827661
    3. Complete cDNA sequence coding for human docking protein. Hortsch M, et al. Nucleic Acids Res, 1988 Jan 11. PMID 3340536, Free PMC Article
    4. The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. Tajima S, et al. J Cell Biol, 1986 Oct. PMID 3021779, Free PMC Article
    5. Signal recognition particle receptor exposes the ribosomal translocon binding site. Halic M, et al. Science, 2006 May 5. PMID 16675701

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
      Title: Human genetic defects in SRP19 and SRPRA cause severe congenital neutropenia with distinctive proteome changes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3650, MGC9571, MGC17355

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding HDA PubMed 
    enables signal recognition particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cotranslational protein targeting to membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal recognition particle receptor subunit alpha
    Names
    DP-alpha
    SR-alpha
    SRP receptor alpha subunit
    SRP-alpha
    docking protein alpha
    signal recognition particle receptor (docking protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177842.2 → NP_001171313.1  signal recognition particle receptor subunit alpha isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AK303379, BC009110
      Consensus CDS
      CCDS53722.1
      UniProtKB/TrEMBL
      Q6IAX9
      Related
      ENSP00000435508.1, ENST00000532259.1
      Conserved Domains (2) summary
      pfam04086
      Location:27 → 234
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal
      cl27330
      Location:269 → 608
      FlhF; Flagellar biosynthesis GTPase FlhF [Cell motility]

    2. NM_003139.4 → NP_003130.2  signal recognition particle receptor subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_003130.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK303379, BC009110
      Consensus CDS
      CCDS31717.1
      UniProtKB/Swiss-Prot
      A6NIB3, B2R5Z8, B4E0H3, E9PJS4, P08240, Q9BVJ4
      UniProtKB/TrEMBL
      Q6IAX9
      Related
      ENSP00000328023.5, ENST00000332118.11
      Conserved Domains (3) summary
      cd17876
      Location:419 → 635
      SRalpha_C; C-terminal domain of signal recognition particle receptor alpha subunit
      pfam02881
      Location:318 → 389
      SRP54_N; SRP54-type protein, helical bundle domain
      pfam04086
      Location:27 → 298
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      126235930..126268895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427497.1 → XP_047283453.1  signal recognition particle receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      Q6IAX9

    2. XM_017018179.3 → XP_016873668.1  signal recognition particle receptor subunit alpha isoform X2

      UniProtKB/TrEMBL
      Q6IAX9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      126265417..126298379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369754.1 → XP_054225729.1  signal recognition particle receptor subunit alpha isoform X1

      UniProtKB/TrEMBL
      Q6IAX9

    2. XM_054369755.1 → XP_054225730.1  signal recognition particle receptor subunit alpha isoform X2

      UniProtKB/TrEMBL
      Q6IAX9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08240.2 GenPept UniProtKB/Swiss-Prot:P08240

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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