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    DNAJB8 DnaJ heat shock protein family (Hsp40) member B8 [ Homo sapiens (human) ]

    Gene ID: 165721, updated on 27-Nov-2024

    Summary

    Official Symbol
    DNAJB8provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B8provided by HGNC
    Primary source
    HGNC:HGNC:23699
    See related
    Ensembl:ENSG00000179407 MIM:611337; AllianceGenome:HGNC:23699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ6; CT156
    Summary
    The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
    Expression
    Restricted expression toward testis (RPKM 16.6) See more
    Orthologs
    NEW
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    Genomic context

    See DNAJB8 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (128462437..128466890, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (131204036..131208509, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128181280..128185733, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128150709-128151289 Neighboring gene uncharacterized LOC124909428 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128151290-128151869 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128151870-128152450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128154435-128155122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20483 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128170962-128171462 Neighboring gene uncharacterized LOC124909429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128177612-128178132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128178133-128178652 Neighboring gene DNAJB8 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128202328-128202892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128202893-128203457 Neighboring gene GATA binding protein 2 Neighboring gene CRISPRi-FlowFISH-validated H1-10 regulatory element 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128208361-128209172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128209173-128209982 Neighboring gene GATA2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14707 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:128223035-128224234 Neighboring gene uncharacterized LOC90246

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33884

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 8
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 8
    testicular tissue protein Li 56

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153330.6NP_699161.1  dnaJ homolog subfamily B member 8

      See identical proteins and their annotated locations for NP_699161.1

      Status: REVIEWED

      Source sequence(s)
      AC080005, KF459586
      Consensus CDS
      CCDS3048.1
      UniProtKB/Swiss-Prot
      B3KWV7, Q8NHS0
      UniProtKB/TrEMBL
      A0A140VJI2
      Related
      ENSP00000316053.3, ENST00000319153.4
      Conserved Domains (1) summary
      COG0484
      Location:3106
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      128462437..128466890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      131204036..131208509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)