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    STX1A syntaxin 1A [ Homo sapiens (human) ]

    Gene ID: 6804, updated on 9-Dec-2024

    Summary

    Official Symbol
    STX1Aprovided by HGNC
    Official Full Name
    syntaxin 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:11433
    See related
    Ensembl:ENSG00000106089 MIM:186590; AllianceGenome:HGNC:11433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STX1; HPC-1; P35-1; SYN1A
    Summary
    This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
    Expression
    Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STX1A in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (73699210..73719669, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (74900126..74920586, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (73113540..73133999, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:73098635-73099484 Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:73099485-73100334 Neighboring gene BUD23 rRNA methyltransferase and ribosome maturation factor Neighboring gene ReSE screen-validated silencer GRCh37_chr7:73104307-73104476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:73113705-73114206 Neighboring gene uncharacterized LOC105375350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:73121477-73122229 Neighboring gene microRNA 4284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:73129777-73130308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18261 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18264 Neighboring gene Sharpr-MPRA regulatory region 8580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26129 Neighboring gene RNA, 7SL, cytoplasmic 265, pseudogene Neighboring gene BICD family like 3, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chloride channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of calcium ion-dependent exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of catecholamine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of norepinephrine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secretion by cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SNARE complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    syntaxin-1A
    Names
    neuron-specific antigen HPC-1
    syntaxin 1A (brain)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013360.1 RefSeqGene

      Range
      5019..25478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001165903.2NP_001159375.1  syntaxin-1A isoform 2

      See identical proteins and their annotated locations for NP_001159375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC000444, BC064644, DA159446
      Consensus CDS
      CCDS55120.1
      UniProtKB/Swiss-Prot
      Q16623
      Related
      ENSP00000378585.3, ENST00000395156.7
      Conserved Domains (1) summary
      pfam00804
      Location:30226
      Syntaxin; Syntaxin
    2. NM_004603.4NP_004594.1  syntaxin-1A isoform 1

      See identical proteins and their annotated locations for NP_004594.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC003011, BC064644, DA159446
      Consensus CDS
      CCDS34655.1
      UniProtKB/Swiss-Prot
      O15447, O15448, Q12936, Q16623, Q75MD9, Q7Z5K3, Q9BPZ6
      UniProtKB/TrEMBL
      Q75ME0, X5D7S1
      Related
      ENSP00000222812.3, ENST00000222812.8
      Conserved Domains (2) summary
      pfam00804
      Location:30227
      Syntaxin
      pfam05739
      Location:228279
      SNARE; SNARE domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      73699210..73719669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420778.1XP_047276734.1  syntaxin-1A isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFZ1
      Related
      ENSP00000378584.3, ENST00000395155.3
    2. XM_047420777.1XP_047276733.1  syntaxin-1A isoform X1

      UniProtKB/TrEMBL
      A8MZ54
      Related
      ENSP00000378583.3, ENST00000395154.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      74900126..74920586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358897.1XP_054214872.1  syntaxin-1A isoform X2

      UniProtKB/TrEMBL
      A0A0C4DFZ1
    2. XM_054358896.1XP_054214871.1  syntaxin-1A isoform X1

      UniProtKB/TrEMBL
      A8MZ54