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    Cyb561d2 cytochrome b-561 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 56368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyb561d2provided by MGI
    Official Full Name
    cytochrome b-561 domain containing 2provided by MGI
    Primary source
    MGI:MGI:1929280
    See related
    Ensembl:ENSMUSG00000037190 AllianceGenome:MGI:1929280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsp10
    Summary
    Enables heme binding activity and transmembrane ascorbate ferrireductase activity. Predicted to be involved in ascorbate homeostasis. Located in endoplasmic reticulum and vesicle. Is expressed in several structures, including Meckel's cartilage; female reproductive system; lower leg mesenchyme; skeleton; and thymus. Orthologous to human CYB561D2 (cytochrome b561 family member D2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.7), adrenal adult (RPKM 15.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cyb561d2 in Genome Data Viewer
    Location:
    9 F1; 9 58.12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107416210..107419392, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107539005..107542193, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 2 Neighboring gene predicted gene, 34037 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107417059-107417168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107423725-107423834 Neighboring gene STARR-positive B cell enhancer ABC_E10583 Neighboring gene STARR-positive B cell enhancer ABC_E10584 Neighboring gene transmembrane protein 115 Neighboring gene STARR-positive B cell enhancer ABC_E3857 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spectral characterization of the recombinant mouse tumor suppressor 101F6 protein. Bérczi A, et al. Eur Biophys J, 2010 Jul. PMID 19943161
    2. Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions. Mizutani A, et al. J Biochem, 2007 Dec. PMID 17938141
    3. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Lerman MI, et al. Cancer Res, 2000 Nov 1. PMID 11085536
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane monodehydroascorbate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane monodehydroascorbate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascorbate homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ascorbate homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane reductase CYB561D2
    Names
    cytochrome b561 domain-containing protein 2
    gene for 101F6 protein
    putative tumor suppressor protein 101F6
    transmembrane ascorbate ferrireductase
    tumor suppressor, region 10
    NP_001344218.1
    NP_001344219.1
    NP_001344220.1
    NP_062694.1
    XP_006511839.1
    XP_030100321.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357289.2 → NP_001344218.1  transmembrane reductase CYB561D2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Consensus CDS
      CCDS23491.1
      UniProtKB/Swiss-Prot
      Q3TRQ1, Q9WUE3
      Related
      ENSMUSP00000141723.2, ENSMUST00000195235.6
      Conserved Domains (1) summary
      cd08761
      Location:25 → 205
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    2. NM_001357290.2 → NP_001344219.1  transmembrane reductase CYB561D2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Conserved Domains (1) summary
      cd08761
      Location:9 → 171
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    3. NM_001357291.2 → NP_001344220.1  transmembrane reductase CYB561D2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Conserved Domains (1) summary
      cd08761
      Location:1 → 154
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    4. NM_001434349.1 → NP_001421278.1  transmembrane reductase CYB561D2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL672219
      UniProtKB/Swiss-Prot
      Q3TRQ1, Q9WUE3

    5. NM_001434350.1 → NP_001421279.1  transmembrane reductase CYB561D2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL672219

    6. NM_019720.5 → NP_062694.1  transmembrane reductase CYB561D2 isoform a

      See identical proteins and their annotated locations for NP_062694.1

      Status: VALIDATED

      Source sequence(s)
      AL672219
      Consensus CDS
      CCDS23491.1
      UniProtKB/Swiss-Prot
      Q3TRQ1, Q9WUE3
      Related
      ENSMUSP00000044093.4, ENSMUST00000041459.9
      Conserved Domains (1) summary
      cd08761
      Location:25 → 205
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107416210..107419392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244461.2 → XP_030100321.1  transmembrane reductase CYB561D2 isoform X1

      Conserved Domains (1) summary
      cd08761
      Location:91 → 253
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    2. XM_006511776.5 → XP_006511839.1  transmembrane reductase CYB561D2 isoform X2

      Conserved Domains (1) summary
      cd08761
      Location:25 → 205
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUE3.1 GenPept UniProtKB/Swiss-Prot:Q9WUE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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