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    Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 [ Mus musculus (house mouse) ]

    Gene ID: 58233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnaja4provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A4provided by MGI
    Primary source
    MGI:MGI:1927638
    See related
    Ensembl:ENSMUSG00000032285 AllianceGenome:MGI:1927638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj4; Hsj4; mmDjA4; 1110021L12Rik
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 35.2), heart adult (RPKM 15.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnaja4 in Genome Data Viewer
    Location:
    9 A5.3; 9 29.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54606132..54623601)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54698848..54716317)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene 5730494N06Rik pseudogene Neighboring gene predicted gene, 46113 Neighboring gene microRNA 5710 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene STARR-positive B cell enhancer ABC_E3830 Neighboring gene cellular retinoic acid binding protein I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. Robichon C, et al. Biochim Biophys Acta, 2006 Sep. PMID 16950652
    2. Murine cDNA encoding a novel type I HSP40/DNAJ homolog, mmDjA4(1). Hata M, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978524
    3. Characterization and functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4. Abdul KM, et al. Cell Stress Chaperones, 2002 Apr. PMID 12380683, Free PMC Article
    4. Quantitative trait Loci specifying the response of body temperature to dietary restriction. Rikke BA, et al. J Gerontol A Biol Sci Med Sci, 2004 Feb. PMID 14999024
    5. Discovery and validation of genes driving drug-intake and related behavioral traits in mice. Roy TA, et al. Genes Brain Behav, 2024 Jan 2. PMID 38164795, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the DnaJA4 chaperone can be viewed as a new player in cholesterol synthesis
      Title: DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway.
    2. hsc70/hsp70-dj4 chaperone pair protects the heart muscle cells from various stresses
      Title: Characterization and functional analysis of a heart-enriched DnaJ/ Hsp40 homolog dj4/DjA4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inclusion body assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily A member 4
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 4
    heat shock protein, DNAJ-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357875.1 → NP_001344804.1  dnaJ homolog subfamily A member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC159892, AK141909, KY499677
      UniProtKB/TrEMBL
      A0A1S6GWG8
      Conserved Domains (1) summary
      cl28246
      Location:15 → 423
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_021422.4 → NP_067397.1  dnaJ homolog subfamily A member 4 isoform 2

      See identical proteins and their annotated locations for NP_067397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC159892, AK076175
      Consensus CDS
      CCDS23193.1
      UniProtKB/Swiss-Prot
      B2RW09, Q543S9, Q9CTD6, Q9CUD4, Q9JMC3
      Related
      ENSMUSP00000070413.8, ENSMUST00000070070.8
      Conserved Domains (4) summary
      cd10719
      Location:135 → 201
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:106 → 332
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2 → 394
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:7 → 65
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54606132..54623601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004935508.1 RNA Sequence

    2. XR_001778951.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMC3.1 GenPept UniProtKB/Swiss-Prot:Q9JMC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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