Gbp7 guanylate binding protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gbp7provided by MGI
Official Full Name: guanylate binding protein 7provided by MGI
Primary source: MGI:MGI:2444421
See related: Ensembl:ENSMUSG00000040253 AllianceGenome:MGI:2444421
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GBP-7; 9830147J24Rik
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including cellular response to interferon-beta; cytolysis in another organism; and defense response to other organism. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in thymus primordium. Orthologous to human GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 4.7), liver E18 (RPKM 2.7) and 23 other tissues See more
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Genomic context

Location:: 3 H1; 3 66.69 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (142236097..142255912)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (142530336..142550151)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-kappaB and JAK-STAT Signaling Pathways.
Title: Inducible Guanylate-Binding Protein 7 Facilitates Influenza A Virus Replication by Suppressing Innate Immunity via NF-κB and JAK-STAT Signaling Pathways.
GBP7 exhibits a concentration-dependent GTPase activity and an apparent GTP turnover number of 20 min-1.
Title: Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail.
findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals
Title: A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adhesion of symbiont to host	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis in another organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type III interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type III interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in symbiont-containing vacuole membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate-binding protein 7

Names: GTP-binding protein 7; guanine nucleotide-binding protein 7; guanylate-binding protein 4-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083312.2 → NP_001076781.1 guanylate-binding protein 7

See identical proteins and their annotated locations for NP_001076781.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC102108, AK087751

Consensus CDS

CCDS38657.1

UniProtKB/Swiss-Prot

Q6KAN1, Q78UK8, Q8BU48, Q91Z40

Related

ENSMUSP00000132970.2, ENSMUST00000171263.8

Conserved Domains (3) summary

pfam02841
Location:283 → 579

GBP_C; Guanylate-binding protein, C-terminal domain

pfam02263
Location:18 → 281

GBP; Guanylate-binding protein, N-terminal domain

cd16269
Location:289 → 579

GBP_C; Guanylate-binding protein, C-terminal domain
NM_145545.4 → NP_663520.2 guanylate-binding protein 7

See identical proteins and their annotated locations for NP_663520.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC102108, AK036666

Consensus CDS

CCDS38657.1

UniProtKB/Swiss-Prot

Q6KAN1, Q78UK8, Q8BU48, Q91Z40

Related

ENSMUSP00000049104.10, ENSMUST00000045097.11

Conserved Domains (3) summary

pfam02841
Location:283 → 579

GBP_C; Guanylate-binding protein, C-terminal domain

pfam02263
Location:18 → 281

GBP; Guanylate-binding protein, N-terminal domain

cd16269
Location:289 → 579

GBP_C; Guanylate-binding protein, C-terminal domain