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    Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 54401, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ywhabprovided by MGI
    Official Full Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideprovided by MGI
    Primary source
    MGI:MGI:1891917
    See related
    Ensembl:ENSMUSG00000018326 AllianceGenome:MGI:1891917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    14-3-3b; 1300003C17Rik
    Summary
    Enables protein domain specific binding activity. Acts upstream of or within protein targeting. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; nervous system; palatal shelf; retina layer; and thymus. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 73.1), CNS E18 (RPKM 72.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ywhab in Genome Data Viewer
    Location:
    2 H3; 2 84.59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163837082..163860508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163995197..164018588)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene predicted gene, 35886 Neighboring gene STARR-positive B cell enhancer ABC_E3417 Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene translocase of outer mitochondrial membrane 34

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables identical protein binding  
    enables identical protein binding  
    enables phosphoprotein binding  
    enables phosphoserine residue binding  
    enables phosphoserine residue binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein domain specific binding  
    enables protein kinase inhibitor activity  
    enables protein kinase inhibitor activity  
    enables protein phosphatase inhibitor activity  
    enables protein-containing complex binding  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in melanosome  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    part_of protein-containing complex  
    part_of transcription repressor complex  

    General protein information

    Preferred Names
    14-3-3 protein beta/alpha
    Names
    14-3-3 protein beta
    KCIP-1
    protein kinase C inhibitor protein 1
    tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418430.1NP_001405359.1  14-3-3 protein beta/alpha

      Status: VALIDATED

      Source sequence(s)
      AL591542
      UniProtKB/Swiss-Prot
      O70455, Q3TY33, Q3UAN6, Q9CQV8
      UniProtKB/TrEMBL
      A2A5N2
    2. NM_001418433.1NP_001405362.1  14-3-3 protein beta/alpha

      Status: VALIDATED

      Source sequence(s)
      AL591542
      UniProtKB/Swiss-Prot
      O70455, Q3TY33, Q3UAN6, Q9CQV8
      UniProtKB/TrEMBL
      A2A5N2
    3. NM_001418434.1NP_001405363.1  14-3-3 protein beta/alpha

      Status: VALIDATED

      Source sequence(s)
      AL591542
      UniProtKB/Swiss-Prot
      O70455, Q3TY33, Q3UAN6, Q9CQV8
      UniProtKB/TrEMBL
      A2A5N2
    4. NM_018753.7NP_061223.2  14-3-3 protein beta/alpha

      See identical proteins and their annotated locations for NP_061223.2

      Status: VALIDATED

      Source sequence(s)
      AL591542
      Consensus CDS
      CCDS17019.1
      UniProtKB/Swiss-Prot
      O70455, Q3TY33, Q3UAN6, Q9CQV8
      UniProtKB/TrEMBL
      A2A5N2
      Related
      ENSMUSP00000018470.4, ENSMUST00000018470.10
      Conserved Domains (1) summary
      cl02098
      Location:4232
      14-3-3; 14-3-3 domain

    RNA

    1. NR_184744.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591542

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163837082..163860508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499909.3XP_006499972.1  14-3-3 protein beta/alpha isoform X1

      See identical proteins and their annotated locations for XP_006499972.1

      UniProtKB/Swiss-Prot
      O70455, Q3TY33, Q3UAN6, Q9CQV8
      UniProtKB/TrEMBL
      A2A5N2
      Conserved Domains (1) summary
      cl02098
      Location:4232
      14-3-3; 14-3-3 domain
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