Ifit1bl2 interferon induced protein with tetratricopeptide repeats 1B like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifit1bl2provided by MGI
Official Full Name: interferon induced protein with tetratricopeptide repeats 1B like 2provided by MGI
Primary source: MGI:MGI:2148249
See related: Ensembl:ENSMUSG00000067297 AllianceGenome:MGI:2148249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifit1b; 2010002M12Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 4.7), small intestine adult (RPKM 3.6) and 4 other tissues See more
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Genomic context

Location:: 19 C1; 19 29.76 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34594446..34618163, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34617046..34640827, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Title: Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Z19543 (e-PCR)
- UniSTS:163481

NoName (e-PCR)
- UniSTS:487393

AW412491 (e-PCR)
- UniSTS:181225

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon induced protein with tetratricopeptide repeats 1B like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362130.1 → NP_001349059.1 interferon induced protein with tetratricopeptide repeats 1B like 2

Status: VALIDATED

Source sequence(s)

AC016791

Consensus CDS

CCDS29765.1

UniProtKB/TrEMBL

Q3U687

Conserved Domains (2) summary

sd00006
Location:282 → 329

TPR; TPR repeat [structural motif]

cl26002
Location:63 → 353

TPR_11; TPR repeat
NM_053217.3 → NP_444447.1 interferon induced protein with tetratricopeptide repeats 1B like 2

See identical proteins and their annotated locations for NP_444447.1

Status: VALIDATED

Source sequence(s)

AK136525, AK153247

Consensus CDS

CCDS29765.1

UniProtKB/TrEMBL

Q3U687

Related

ENSMUSP00000093816.3, ENSMUST00000087357.5

Conserved Domains (2) summary

sd00006
Location:282 → 329

TPR; TPR repeat [structural motif]

cl26002
Location:63 → 353

TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

34594446..34618163 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250699.2 → XP_030106559.1 interferon induced protein with tetratricopeptide repeats 1B like 2 isoform X1

Conserved Domains (3) summary

TIGR02521
Location:263 → 340

type_IV_pilW; type IV pilus biogenesis/stability protein PilW

TIGR02917
Location:2 → 292

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:221 → 268

TPR; TPR repeat [structural motif]