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    Zfp729a zinc finger protein 729a [ Mus musculus (house mouse) ]

    Gene ID: 212281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp729aprovided by MGI
    Official Full Name
    zinc finger protein 729aprovided by MGI
    Primary source
    MGI:MGI:3036250
    See related
    Ensembl:ENSMUSG00000021510 AllianceGenome:MGI:3036250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rslcan3; A530054K11Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF729 (zinc finger protein 729). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.6), CNS E18 (RPKM 1.4) and 25 other tissues See more
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    Genomic context

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    See Zfp729a in Genome Data Viewer
    Location:
    13 B3; 13 34.62 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67760879..67785925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67612760..67637803, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9430065F17 gene Neighboring gene STARR-positive B cell enhancer ABC_E9881 Neighboring gene zinc finger protein 729b Neighboring gene STARR-positive B cell enhancer ABC_E4077 Neighboring gene STARR-seq mESC enhancer starr_34905 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67738709-67738896 Neighboring gene predicted gene, 46439 Neighboring gene STARR-seq mESC enhancer starr_34906 Neighboring gene zinc finger protein 738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
    2. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC212281
    Names
    regulator of sex-limitation candidate 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401864.1 → NP_001388793.1  uncharacterized protein LOC212281 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT571249, CT573016

    2. NM_001401865.1 → NP_001388794.1  uncharacterized protein LOC212281 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT571249, CT573016

    3. NM_001401866.1 → NP_001388795.1  uncharacterized protein LOC212281 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT571249, CT573016

    4. NM_183146.5 → NP_898969.2  uncharacterized protein LOC212281 isoform 1

      See identical proteins and their annotated locations for NP_898969.2

      Status: VALIDATED

      Source sequence(s)
      CT571249, CT573016
      Consensus CDS
      CCDS26617.1
      UniProtKB/TrEMBL
      Q4QQP3
      Related
      ENSMUSP00000012314.8, ENSMUST00000012314.10
      Conserved Domains (5) summary
      smart00349
      Location:15 → 73
      KRAB; krueppel associated box
      COG5048
      Location:229 → 670
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:485 → 505
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 54
      KRAB; KRAB box
      pfam13465
      Location:497 → 522
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67760879..67785925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157962.1 → XP_036013855.1  uncharacterized protein LOC212281 isoform X2

      Conserved Domains (3) summary
      smart00349
      Location:15 → 73
      KRAB; krueppel associated box
      COG5048
      Location:116 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:233 → 253
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011244504.4 → XP_011242806.1  uncharacterized protein LOC212281 isoform X1

      See identical proteins and their annotated locations for XP_011242806.1

      Conserved Domains (4) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:216 → 657
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:130 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036157961.1 → XP_036013854.1  uncharacterized protein LOC212281 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:216 → 657
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:130 → 199
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:472 → 492
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_873435.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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