Angptl1 angiopoietin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angptl1provided by MGI
Official Full Name: angiopoietin-like 1provided by MGI
Primary source: MGI:MGI:1919963
See related: Ensembl:ENSMUSG00000033544 AllianceGenome:MGI:1919963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ANG3; ANGY; ARP1; ANGPT3; 2810039D03Rik
Summary: Enables signaling receptor binding activity. Acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; heart; intraembryonic coelom; limb mesenchyme; and skeleton. Orthologous to human ANGPTL1 (angiopoietin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in limb E14.5 (RPKM 33.4), CNS E14 (RPKM 3.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 67.75 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (156666495..156688648)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (156839023..156861078)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer.
Title: ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer.
Influence of Angptl1 on osteoclast formation and osteoblastic phenotype in mouse cells.
Title: Influence of Angptl1 on osteoclast formation and osteoblastic phenotype in mouse cells.
We conclude that angptl1 may have a beneficial role in the preservation of vascular integrity following focal cerebral ischemia.
Title: Angiopoietin-like protein 1 decreases blood brain barrier damage and edema following focal cerebral ischemia in mice.
Angiopoietin-like protein 1 expression is related to intermuscular connective tissue and cartilage development
Title: Angiopoietin-like protein 1 expression is related to intermuscular connective tissue and cartilage development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

Angpt1 (e-PCR), detects polymorphism
- UniSTS:545845

Angptl1 (e-PCR), detects polymorphism
- UniSTS:506681

Angptl1 (e-PCR), detects polymorphism
- UniSTS:506688

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-related protein 1

Names: angiopoietin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028333.3 → NP_082609.2 angiopoietin-related protein 1 precursor

See identical proteins and their annotated locations for NP_082609.2

Status: VALIDATED

Source sequence(s)

AC138109

Consensus CDS

CCDS15397.1

UniProtKB/Swiss-Prot

Q3UQL1, Q640P2, Q9CZ81

Related

ENSMUSP00000027885.8, ENSMUST00000027885.8

Conserved Domains (2) summary

cd00087
Location:274 → 489

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl23720
Location:91 → 207

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)