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    tir T3SS translocated intimin receptor Tir [ Escherichia coli O157:H7 str. Sakai ]

    Gene ID: 915465, updated on 6-Oct-2023

    Summary

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    Gene symbol
    tir
    Gene description
    T3SS translocated intimin receptor Tir
    Locus tag
    ECs_4561
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli O157:H7 str. Sakai (strain: Sakai, substrain: RIMD 0509952, serovar: O157:H7)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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    Genomic context

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    Sequence:
    NC_002695.2 (4600055..4601731, complement)

    NC_002695.2Genomic Context describing neighboring genes Neighboring gene T3SS intimin Neighboring gene T3SS chaperone CesT Neighboring gene T3SS secreted effector Map Neighboring gene T3SS chaperone CesF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002695.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The established intimin receptor Tir and the putative eucaryotic intimin receptors nucleolin and beta1 integrin localize at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in vivo. Sinclair JF, et al. Infect Immun, 2006 Feb. PMID 16428775, Free PMC Article
    2. A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion. Allen-Vercoe E, et al. FEMS Microbiol Lett, 2005 Feb 15. PMID 15686835
    3. Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor. Sinclair JF, et al. J Biol Chem, 2004 Aug 6. PMID 15173179
    4. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA. McNeilly TN, et al. PLoS One, 2015. PMID 26020530, Free PMC Article
    5. Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. Cantarelli VV, et al. Cell Microbiol, 2007 Jul. PMID 17451412

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA
      Title: Optimizing the Protection of Cattle against Escherichia coli O157:H7 Colonization through Immunization with Different Combinations of H7 Flagellin, Tir, Intimin-531 or EspA.
    2. identified a 6 amino acid (519-524) carboxy-terminal region which was required for efficient Tir secretion and translocation; data suggest that this region may play a role in maintaining EHEC O157:H7 Tir in a secretion-competent conformation
      Title: A carboxy-terminal domain of Tir from enterohemorrhagic Escherichia coli O157:H7 (EHEC O157:H7) required for efficient type III secretion.
    3. localizes at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in piglets, neonatal calves, and mice.
      Title: The established intimin receptor Tir and the putative eucaryotic intimin receptors nucleolin and beta1 integrin localize at or near the site of enterohemorrhagic Escherichia coli O157:H7 adherence to enterocytes in vivo.
    4. Binding of cortactin to Tir and EspF(u), is dependent upon tyrosine phosphorylation and a balance between tyrosine phosphorylation and dephosphorylation of cortactin is required to regulate pedestal formation by EHEC.
      Title: Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    T3SS translocated intimin receptor Tir

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002695.2 Reference assembly

      Range
      4600055..4601731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_312588.1 T3SS translocated intimin receptor Tir [Escherichia coli O157:H7 str. Sakai]

      See identical proteins and their annotated locations for NP_312588.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      E2IPB9
      Conserved Domains (3) summary
      pfam07490
      Location:1 → 267
      Tir_receptor_N; Translocated intimin receptor (Tir) N-terminus
      pfam03549
      Location:269 → 333
      Tir_receptor_M; Translocated intimin receptor (Tir) intimin-binding domain
      pfam07489
      Location:334 → 558
      Tir_receptor_C; Translocated intimin receptor (Tir) C-terminus
    Nucleotide Protein
    Heading Accession and Version

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