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    ppk polyphosphate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946971, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ppk
    Official Full Name
    polyphosphate kinase
    Primary source
    ECOCYC:EG11510
    Locus tag
    b2501
    See related
    ASAP:ABE-0008235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2497
    Summary
    The role of polyphosphate (poly(Pi)) in Escherichia coli is still not fully understood; it may function in energy storage. [More information is available at EcoCyc: EG11510].
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    Genomic context

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    Sequence:
    NC_000913.3 (2623044..2625110)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylformylglycinamide cyclo-ligase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene exopolyphosphatase Neighboring gene cyclic di-GMP phosphodiesterase PdeF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inorganic polyphosphate is required for motility of bacterial pathogens. Rashid MH, et al. J Bacteriol, 2000 Jan. PMID 10613886, Free PMC Article
    2. Catalytic properties of Escherichia coli polyphosphate kinase: an enzyme for ATP regeneration. Haeusler PA, et al. Biotechnol Appl Biochem, 1992 Apr. PMID 1316760
    3. The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein. Akiyama M, et al. J Biol Chem, 1992 Nov 5. PMID 1331061
    4. Genetically altered levels of inorganic polyphosphate in Escherichia coli. Crooke E, et al. J Biol Chem, 1994 Mar 4. PMID 8119977
    5. Phosphohistidyl active sites in polyphosphate kinase of Escherichia coli. Kumble KD, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962061, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using Escherichia coli as a model organism, we have identified the first known mutations in polyP kinase that lead to increases in cellular polyP content.
      Title: Mutations in Escherichia coli Polyphosphate Kinase That Lead to Dramatically Increased In Vivo Polyphosphate Levels.
    2. These results indicate that ppk1 plays an important role in stress adaptation and virulence in meningitic E. coli K1 strain E44.
      Title: Polyphosphate kinase 1 is required for the pathogenesis process of meningitic Escherichia coli K1 (RS218).
    3. N-terminus verified by Edman degradation on mature peptide
      Title: The polyphosphate kinase gene of Escherichia coli. Isolation and sequence of the ppk gene and membrane location of the protein.
    4. Ppk is required for the increased rate of growth-dependent mutations produced by Pol IV overexpression; results suggest Ppk is affecting the activity of Pol IV in a manner that is independent of any previously known factors that regulate this polymerase
      Title: Polyphosphate kinase regulates error-prone replication by DNA polymerase IV in Escherichia coli.
    5. crystal structures of full-length Escherichia coli PPK and its complex with AMPPNP (beta-gamma-imidoadenosine 5-phosphate)is reported.
      Title: Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diphosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polyphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyphosphate:AMP phosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorus metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within polyphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in polyphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in periplasmic side of cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of polyphosphate kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of polyphosphate kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyphosphate kinase
    NP_416996.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2623044..2625110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416996.1 polyphosphate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416996.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M4G5
      Conserved Domains (1) summary
      COG0855
      Location:2 → 688
      Ppk; Polyphosphate kinase [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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