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    sgbH 3-keto-L-gulonate-6-phosphate decarboxylase SgbH [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948098, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sgbH
    Official Full Name
    3-keto-L-gulonate-6-phosphate decarboxylase SgbH
    Primary source
    ECOCYC:EG12285
    Locus tag
    b3581
    See related
    ASAP:ABE-0011698
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3570; yiaQ
    Summary
    YiaQ is possibly involved in the utilization of L-dehydroascorbate (2,3-diketo-L-gulonate) (Yew, 2002). [More information is available at EcoGene: EG12285].
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    Genomic context

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    Sequence:
    NC_000913.3 (3748577..3749239)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2,3-diketo-L-gulonate:Na(+) symporter - membrane subunit Neighboring gene 2,3-diketo-L-gulonate:Na(+) symporter - periplasmic binding protein Neighboring gene L-xylulose kinase Neighboring gene putative L-xylulose 5-phosphate 3-epimerase Neighboring gene L-ribulose-5-phosphate 4-epimerase SgbE Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase. Yew WS, et al. Biochemistry, 2005 Feb 15. PMID 15697206
    2. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: crystallographic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase. Wise EL, et al. Biochemistry, 2004 Jun 1. PMID 15157078
    3. Transporter's evolution and carbohydrate metabolic clusters. Plantinga TH, et al. Trends Microbiol, 2004 Jan. PMID 14700544
    4. Aerobic L-ascorbate metabolism and associated oxidative stress in Escherichia coli. Campos E, et al. Microbiology (Reading), 2007 Oct. PMID 17906139
    5. A rare 920-kilobase chromosomal inversion mediated by IS1 transposition causes constitutive expression of the yiaK-S operon for carbohydrate utilization in Escherichia coli. Badía J, et al. J Biol Chem, 1998 Apr 3. PMID 9525947

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-dehydro-L-gulonate-6-phosphate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-dehydro-L-gulonate-6-phosphate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-dehydro-L-gulonate-6-phosphate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orotidine-5'-phosphate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-ascorbic acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-keto-L-gulonate-6-phosphate decarboxylase SgbH
    NP_418038.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3748577..3749239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418038.1 3-keto-L-gulonate-6-phosphate decarboxylase SgbH [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418038.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YKB5
      Conserved Domains (1) summary
      PRK13305
      Location:1 → 217
      sgbH; 3-keto-L-gulonate-6-phosphate decarboxylase UlaD
    Nucleotide Protein
    Heading Accession and Version

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