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    Orc5 origin recognition complex, subunit 5 [ Mus musculus (house mouse) ]

    Gene ID: 26429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orc5provided by MGI
    Official Full Name
    origin recognition complex, subunit 5provided by MGI
    Primary source
    MGI:MGI:1347044
    See related
    Ensembl:ENSMUSG00000029012 AllianceGenome:MGI:1347044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orc5l; MmORC5
    Summary
    Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and regulation of DNA replication. Predicted to act upstream of or within DNA replication. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human ORC5 (origin recognition complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 8.3), liver E14.5 (RPKM 7.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Orc5 in Genome Data Viewer
    Location:
    5 A3; 5 10.07 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22691478..22755358, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (22486480..22550338, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene reelin Neighboring gene predicted gene, 54324 Neighboring gene STARR-seq mESC enhancer starr_12584 Neighboring gene predicted gene, 42223 Neighboring gene predicted gene, 25459 Neighboring gene STARR-seq mESC enhancer starr_12585 Neighboring gene STARR-seq mESC enhancer starr_12586 Neighboring gene STARR-seq mESC enhancer starr_12587 Neighboring gene RIKEN cDNA 6030443J06 gene Neighboring gene STARR-seq mESC enhancer starr_12588 Neighboring gene STARR-seq mESC enhancer starr_12589 Neighboring gene ribosomal protein L22 like 1 pseudogene Neighboring gene predicted gene, 22887 Neighboring gene predicted gene, 42225 Neighboring gene ubiquitin-conjugating enzyme E2 L3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. Springer J, et al. Chromosoma, 1999 Aug. PMID 10460412
    2. The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Jaremko MJ, et al. Elife, 2020 Aug 18. PMID 32808929, Free PMC Article
    3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nuclear origin of replication recognition complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 5
    Names
    origin recognition complex, subunit 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429001.1 → NP_001415930.1  origin recognition complex subunit 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121548

    2. NM_001429002.1 → NP_001415931.1  origin recognition complex subunit 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121548

    3. NM_001429003.1 → NP_001415932.1  origin recognition complex subunit 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121548

    4. NM_011959.4 → NP_036089.1  origin recognition complex subunit 5 isoform 1

      See identical proteins and their annotated locations for NP_036089.1

      Status: VALIDATED

      Source sequence(s)
      AC121548
      Consensus CDS
      CCDS19110.1
      UniProtKB/Swiss-Prot
      Q3TMI6, Q9WUV0
      Related
      ENSMUSP00000030872.6, ENSMUST00000030872.12
      Conserved Domains (3) summary
      COG1474
      Location:11 → 191
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam13191
      Location:8 → 155
      AAA_16; AAA ATPase domain
      pfam14630
      Location:177 → 431
      ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      22691478..22755358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535716.5 → XP_006535779.1  origin recognition complex subunit 5 isoform X1

      Conserved Domains (2) summary
      pfam13191
      Location:1 → 62
      AAA_16; AAA ATPase domain
      pfam14630
      Location:84 → 338
      ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus

    2. XM_036165143.1 → XP_036021036.1  origin recognition complex subunit 5 isoform X1

      Conserved Domains (2) summary
      pfam13191
      Location:1 → 62
      AAA_16; AAA ATPase domain
      pfam14630
      Location:84 → 338
      ORC5_C; Origin recognition complex (ORC) subunit 5 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUV0.1 GenPept UniProtKB/Swiss-Prot:Q9WUV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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