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    Pcdhb19 protocadherin beta 19 [ Mus musculus (house mouse) ]

    Gene ID: 93890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcdhb19provided by MGI
    Official Full Name
    protocadherin beta 19provided by MGI
    Primary source
    MGI:MGI:2136757
    See related
    Ensembl:ENSMUSG00000043313 AllianceGenome:MGI:2136757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PcdhbS; Pcdhb11
    Summary
    Predicted to be involved in cell adhesion. Predicted to be active in plasma membrane. Is expressed in central nervous system and retina. Orthologous to several human genes including PCDHB12 (protocadherin beta 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Pcdhb19 in Genome Data Viewer
    Location:
    18 B3; 18 19.51 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37630049..37637181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37496998..37501711)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 17 Neighboring gene protocadherin beta 18 Neighboring gene protocadherin beta 20 Neighboring gene protocadherin beta 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Hirano K, et al. Front Mol Neurosci, 2012. PMID 22969705, Free PMC Article
    2. An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation. Inoue YU, et al. Cells, 2021 Apr 30. PMID 33946570, Free PMC Article
    3. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Junghans D, et al. Eur J Neurosci, 2008 Feb. PMID 18279309
    4. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
    5. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin beta 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053144.3 → NP_444374.2  protocadherin beta 19 precursor

      See identical proteins and their annotated locations for NP_444374.2

      Status: VALIDATED

      Source sequence(s)
      AC020967
      Consensus CDS
      CCDS29185.1
      UniProtKB/TrEMBL
      Q3UH89, Q91Y01, Q925L2
      Related
      ENSMUSP00000053326.6, ENSMUST00000059571.7
      Conserved Domains (3) summary
      cd11304
      Location:247 → 343
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:32 → 112
      Cadherin_2; Cadherin-like
      pfam16492
      Location:687 → 769
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37630049..37637181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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