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    Acaa1b acetyl-Coenzyme A acyltransferase 1B [ Mus musculus (house mouse) ]

    Gene ID: 235674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acaa1bprovided by MGI
    Official Full Name
    acetyl-Coenzyme A acyltransferase 1Bprovided by MGI
    Primary source
    MGI:MGI:3605455
    See related
    Ensembl:ENSMUSG00000010651 AllianceGenome:MGI:3605455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable acetate CoA-transferase activity; acetyl-CoA C-acyltransferase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in monocarboxylic acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; metencephalon basal plate; and submandibular gland primordium. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 383.0), kidney adult (RPKM 114.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acaa1b in Genome Data Viewer
    Location:
    9 F3; 9 71.33 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118977111..118986149, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119148043..119157093, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene villin-like Neighboring gene predicted gene, 51697 Neighboring gene phospholipase C, delta 1 Neighboring gene STARR-positive B cell enhancer ABC_E9778 Neighboring gene STARR-positive B cell enhancer ABC_E9779 Neighboring gene deleted in lung and esophageal cancer 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide pseudogene Neighboring gene solute carrier family 22 (organic cation transporter), member 14 Neighboring gene STARR-seq mESC enhancer starr_25468

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver. Fidaleo M, et al. Biochimie, 2011 May. PMID 21352884
    2. Modulation of the hepatic fatty acid pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective PPARalpha agonist Wy14,643. Arnauld S, et al. Biochimie, 2009 Nov-Dec. PMID 19772884
    3. Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes. Chevillard G, et al. BMC Biochem, 2004 Mar 25. PMID 15043762, Free PMC Article
    4. Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism. Chevillard G, et al. Biochimie, 2004 Nov. PMID 15589695
    5. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. acetyl-Coenzyme A acyltransferase 1B is involved in the regulation of genes encoding cholesterol biosynthesis enzymes in the liver
      Title: A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.
    2. Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase B.
      Title: Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes.
    3. The region of the peroxisomal 3-ketoacyl-CoA thiolase B gene encoding the catalytic site was disrupted by homologous recombination in order to analyze the phenotype of these thiolase B-deficient mice.
      Title: Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29978

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetate CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyl-CoA C-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA C-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA C-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-CoA oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-ketoacyl-CoA thiolase B, peroxisomal
    Names
    acetyl-CoA acyltransferase B
    beta-ketothiolase B
    peroxisomal 3-oxoacyl-CoA thiolase B
    NP_001397554.1
    NP_666342.1
    XP_006512179.1
    XP_011241272.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410625.1 → NP_001397554.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC055818
      UniProtKB/TrEMBL
      Q8BLD7

    2. NM_146230.4 → NP_666342.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform 1 precursor

      See identical proteins and their annotated locations for NP_666342.1

      Status: VALIDATED

      Source sequence(s)
      AC055818
      Consensus CDS
      CCDS23608.1
      UniProtKB/Swiss-Prot
      Q8VCH0
      UniProtKB/TrEMBL
      Q3TUU3, Q3UKM0
      Related
      ENSMUSP00000010795.5, ENSMUST00000010795.5
      Conserved Domains (2) summary
      PLN02287
      Location:1 → 420
      PLN02287; 3-ketoacyl-CoA thiolase
      cd00751
      Location:39 → 421
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      118977111..118986149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242970.1 → XP_011241272.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform X1

      UniProtKB/TrEMBL
      Q3TUU3
      Conserved Domains (1) summary
      PLN02287
      Location:23 → 356
      PLN02287; 3-ketoacyl-CoA thiolase

    2. XM_006512116.5 → XP_006512179.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform X3

      See identical proteins and their annotated locations for XP_006512179.1

      UniProtKB/TrEMBL
      H3BKA1
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 209
      PLN02287; 3-ketoacyl-CoA thiolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCH0.1 GenPept UniProtKB/Swiss-Prot:Q8VCH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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