mt-Nd5 NADH dehydrogenase 5, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Nd5provided by MGI
Official Full Name: NADH dehydrogenase 5, mitochondrialprovided by MGI
Primary source: MGI:MGI:102496
See related: AllianceGenome:MGI:102496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ND5
Summary: Contributes to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in central nervous system; heart; liver; metanephros; and retina. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. Orthologous to human MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (11742..13565)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (11742..13565)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

variations in mtDNA encoded complex I genes, mt-Nd2 and mt-Nd5, differentially affected lifespan and metabolic phenotypes
Title: Maternally Inherited Differences within Mitochondrial Complex I Control Murine Healthspan.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136205 (e-PCR)
- UniSTS:210200

RH136233 (e-PCR)
- UniSTS:210227

PMC85197P1 (e-PCR)
- UniSTS:273467

RH136521 (e-PCR)
- UniSTS:210503

RH136257 (e-PCR)
- UniSTS:210250

mt-Nd6 (e-PCR), detects polymorphism
- UniSTS:496723

RH136536 (e-PCR)
- UniSTS:210518

RH136274 (e-PCR)
- UniSTS:210267

RH136285 (e-PCR)
- UniSTS:210278

NoName (e-PCR)
- UniSTS:234089

NoName (e-PCR)
- UniSTS:234092

RH136370 (e-PCR)
- UniSTS:210360

RH136382 (e-PCR)
- UniSTS:210372

RH136397 (e-PCR)
- UniSTS:210387

RH125467 (e-PCR)
- UniSTS:162286

RH125521 (e-PCR)
- UniSTS:162286

Homology

Orthologs from OrthoDB

variation

Loc: 13052 replace = c

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to NADH dehydrogenase (ubiquinone) activity	IDA Inferred from Direct Assay more info	PubMed
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in electron transport coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info