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    Relch RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [ Mus musculus (house mouse) ]

    Gene ID: 227446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Relchprovided by MGI
    Official Full Name
    RAB11 binding and LisH domain, coiled-coil and HEAT repeat containingprovided by MGI
    Primary source
    MGI:MGI:1922832
    See related
    Ensembl:ENSMUSG00000026319 AllianceGenome:MGI:1922832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1468; mKIAA1468; 6430401N10; 2310035C23Rik
    Summary
    Predicted to be involved in intracellular cholesterol transport. Located in recycling endosome. Is expressed in central nervous system and ganglia. Orthologous to human RELCH (RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 9.9), bladder adult (RPKM 8.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Relch in Genome Data Viewer
    Location:
    1 E2.1; 1 49.64 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105591570..105682856)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105663843..105755131)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class N Neighboring gene 60S ribosomal protein L37a-like Neighboring gene STARR-positive B cell enhancer mm9_chr1:107527155-107527456 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:107559805-107559992 Neighboring gene STARR-positive B cell enhancer ABC_E988 Neighboring gene predicted gene 10193 Neighboring gene tumor necrosis factor receptor superfamily, member 11a, NFKB activator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution. Sobajima T, et al. J Cell Biol, 2018 May 7. PMID 29514919, Free PMC Article
    2. Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction. Hiday AC, et al. Neural Plast, 2017. PMID 28634551, Free PMC Article
    3. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular cholesterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RAB11-binding protein RELCH
    Names
    RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029349.2 → NP_083625.1  RAB11-binding protein RELCH isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC101816, AC166354
      Consensus CDS
      CCDS48334.1
      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      UniProtKB/TrEMBL
      A0A087WSS1
      Related
      ENSMUSP00000141162.2, ENSMUST00000190501.7
      Conserved Domains (1) summary
      sd00044
      Location:495 → 527
      HEAT; HEAT repeat [structural motif]

    2. NM_173187.4 → NP_775279.2  RAB11-binding protein RELCH isoform 1

      See identical proteins and their annotated locations for NP_775279.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC101816, AC166354
      Consensus CDS
      CCDS15206.1
      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      UniProtKB/TrEMBL
      E9QM90
      Related
      ENSMUSP00000039178.7, ENSMUST00000039173.13
      Conserved Domains (1) summary
      sd00044
      Location:519 → 551
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      105591570..105682856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529501.4 → XP_006529564.1  RAB11-binding protein RELCH isoform X1

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:1012 → 1040
      HEAT; HEAT repeat [structural motif]

    2. XM_006529507.4 → XP_006529570.1  RAB11-binding protein RELCH isoform X11

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:1012 → 1040
      HEAT; HEAT repeat [structural motif]

    3. XM_006529502.4 → XP_006529565.1  RAB11-binding protein RELCH isoform X2

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:648 → 677
      HEAT; HEAT repeat [structural motif]

    4. XM_006529503.4 → XP_006529566.1  RAB11-binding protein RELCH isoform X3

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:1009 → 1037
      HEAT; HEAT repeat [structural motif]

    5. XM_006529504.4 → XP_006529567.1  RAB11-binding protein RELCH isoform X4

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:1008 → 1036
      HEAT; HEAT repeat [structural motif]

    6. XM_030253824.1 → XP_030109684.1  RAB11-binding protein RELCH isoform X12

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519 → 551
      HEAT; HEAT repeat [structural motif]

    7. XM_006529505.4 → XP_006529568.1  RAB11-binding protein RELCH isoform X5

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      UniProtKB/TrEMBL
      G3X9J4
      Related
      ENSMUSP00000083926.5, ENSMUST00000086721.10
      Conserved Domains (1) summary
      sd00044
      Location:519 → 551
      HEAT; HEAT repeat [structural motif]

    8. XM_036164603.1 → XP_036020496.1  RAB11-binding protein RELCH isoform X6

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519 → 551
      HEAT; HEAT repeat [structural motif]

    9. XM_030253811.1 → XP_030109671.1  RAB11-binding protein RELCH isoform X7

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519 → 551
      HEAT; HEAT repeat [structural motif]

    10. XM_036164608.1 → XP_036020501.1  RAB11-binding protein RELCH isoform X13

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:519 → 551
      HEAT; HEAT repeat [structural motif]

    11. XM_006529506.5 → XP_006529569.1  RAB11-binding protein RELCH isoform X8

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:988 → 1016
      HEAT; HEAT repeat [structural motif]

    12. XM_030253819.1 → XP_030109679.1  RAB11-binding protein RELCH isoform X9

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:495 → 527
      HEAT; HEAT repeat [structural motif]

    13. XM_036164606.1 → XP_036020499.1  RAB11-binding protein RELCH isoform X10

      UniProtKB/Swiss-Prot
      Q148V6, Q148V7, Q6PAN5, Q6ZPQ2, Q8C9Z0, Q8CCT3, Q8CD48
      Conserved Domains (1) summary
      sd00044
      Location:495 → 527
      HEAT; HEAT repeat [structural motif]

    14. XM_036164611.1 → XP_036020504.1  RAB11-binding protein RELCH isoform X16

      Conserved Domains (1) summary
      sd00044
      Location:133 → 165
      HEAT; HEAT repeat [structural motif]

    15. XM_036164609.1 → XP_036020502.1  RAB11-binding protein RELCH isoform X14

      Conserved Domains (1) summary
      sd00044
      Location:626 → 654
      HEAT; HEAT repeat [structural motif]

    16. XM_036164610.1 → XP_036020503.1  RAB11-binding protein RELCH isoform X15

      Conserved Domains (1) summary
      sd00044
      Location:133 → 165
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_001784195.2 RNA Sequence

    2. XR_001784196.2 RNA Sequence

    3. XR_001784197.3 RNA Sequence

    4. XR_004942063.1 RNA Sequence

    5. XR_001784198.3 RNA Sequence

    6. XR_387169.4 RNA Sequence

      Related
      ENSMUST00000186807.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q148V7.1 GenPept UniProtKB/Swiss-Prot:Q148V7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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