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    Cyp2d12 cytochrome P450, family 2, subfamily d, polypeptide 12 [ Mus musculus (house mouse) ]

    Gene ID: 380997, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cyp2d12provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily d, polypeptide 12provided by MGI
    Primary source
    MGI:MGI:88604
    See related
    Ensembl:ENSMUSG00000096852 AllianceGenome:MGI:88604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030605E09Rik
    Summary
    Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 25.1), kidney adult (RPKM 22.9) and 2 other tissues See more
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    Genomic context

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    See Cyp2d12 in Genome Data Viewer
    Location:
    15 E1; 15 38.64 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82439244..82443614)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82555043..82559413)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46524 Neighboring gene STARR-seq mESC enhancer starr_39297 Neighboring gene predicted gene, 28023 Neighboring gene STARR-seq mESC enhancer starr_39298 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 33, pseudogene Neighboring gene STARR-seq mESC enhancer starr_39299 Neighboring gene STARR-seq mESC enhancer starr_39300 Neighboring gene STARR-seq mESC enhancer starr_39301 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 34, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. Nelson DR, et al. DNA Cell Biol, 1993 Jan-Feb. PMID 7678494
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anandamide 11,12 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 8,9 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily d, polypeptide 12
    Names
    cytochrome P450, 2d12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355665.1 → NP_001342594.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132878
      Consensus CDS
      CCDS88815.1
      UniProtKB/TrEMBL
      B7ZP10, D3Z6U9
      Related
      ENSMUSP00000154856.2, ENSMUST00000229904.2
      Conserved Domains (1) summary
      pfam00067
      Location:37 → 445
      p450; Cytochrome P450

    2. NM_201360.2 → NP_958748.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform 1

      See identical proteins and their annotated locations for NP_958748.1

      Status: VALIDATED

      Source sequence(s)
      AC132878
      Consensus CDS
      CCDS37160.1
      UniProtKB/TrEMBL
      Q8BVD2
      Related
      ENSMUSP00000071064.7, ENSMUST00000068861.8
      Conserved Domains (1) summary
      pfam00067
      Location:37 → 496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82439244..82443614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521128.3 → XP_006521191.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X1

      See identical proteins and their annotated locations for XP_006521191.1

      Conserved Domains (1) summary
      pfam00067
      Location:12 → 471
      p450; Cytochrome P450

    2. XM_006521132.2 → XP_006521195.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X3

      See identical proteins and their annotated locations for XP_006521195.1

      Conserved Domains (1) summary
      pfam00067
      Location:1 → 421
      p450; Cytochrome P450

    3. XM_006521130.1 → XP_006521193.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:37 → 437
      p450; Cytochrome P450

    4. XM_006521131.1 → XP_006521194.1  cytochrome P450, family 2, subfamily d, polypeptide 12 isoform X3

      See identical proteins and their annotated locations for XP_006521194.1

      Conserved Domains (1) summary
      pfam00067
      Location:1 → 421
      p450; Cytochrome P450

    RNA

    1. XR_875302.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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