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    IMA4 oligo-1,6-glucosidase IMA4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IMA4
    Official Full Name
    oligo-1,6-glucosidase IMA4
    Primary source
    SGD:S000003757
    Locus tag
    YJL221C
    See related
    AllianceGenome:SGD:S000003757; FungiDB:YJL221C; VEuPathDB:YJL221C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FSP2
    Summary
    Enables oligo-1,6-glucosidase activity. Involved in disaccharide catabolic process. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IMA4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (16767..18536, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene seripauperin PAU1 Neighboring gene signal sequence-binding protein Neighboring gene hexose transporter HXT9 Neighboring gene acetyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional genomic analysis of a commercial wine strain of Saccharomyces cerevisiae under differing nitrogen conditions. Backhus LE, et al. FEMS Yeast Res, 2001 Jul. PMID 12702356
    2. Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae. Naumoff DG, et al. Dokl Biochem Biophys, 2010 May-Jun. PMID 20886742
    3. Sequence analysis of a 40.2 kb DNA fragment located near the left telomere of yeast chromosome X. Vandenbol M, et al. Yeast, 1994 Dec. PMID 7725802
    4. Different levels of catabolite repression optimize growth in stable and variable environments. New AM, et al. PLoS Biol, 2014 Jan. PMID 24453942, Free PMC Article
    5. Inhibition kinetics of flavonoids on yeast α-glucosidase merged with docking simulations. Xu H. Protein Pept Lett, 2010 Oct. PMID 20518737

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan 1,4-alpha-maltotriohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligo-1,6-glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligo-1,6-glucosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sucrose alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in disaccharide catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maltose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maltose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sucrose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    oligo-1,6-glucosidase IMA4
    NP_012314.1
    • Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      16767..18536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181654.1 → NP_012314.1  TPA: oligo-1,6-glucosidase IMA4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012314.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVX6, P0CW40, P0CW41, P40439
      UniProtKB/TrEMBL
      E1AFY9, G2WFX9
      Conserved Domains (2) summary
      cd11333
      Location:16 → 503
      AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins
      pfam16657
      Location:514 → 585
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CW40.1
    P0CW41.1

    Gene LinkOut

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