MAS1 mitochondrial processing peptidase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MAS1
Official Full Name: mitochondrial processing peptidase
Primary source: SGD:S000004153
Locus tag: YLR163C
See related: AllianceGenome:SGD:S000004153; FungiDB:YLR163C; VEuPathDB:YLR163C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MIF1
Summary: Contributes to metalloendopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Part of mitochondrial processing peptidase complex. Used to study multiple mitochondrial dysfunctions syndrome 6. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple mitochondrial dysfunctions syndrome 6. Orthologous to several human genes including PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MAS1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (491866..493254, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing involved in protein targeting to mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
part_of mitochondrial processing peptidase complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial processing peptidase

NP_013264.1

EC 3.4.24.64

Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

491866..493254 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182050.1 → NP_013264.1 TPA: mitochondrial processing peptidase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013264.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYG9, P10507

UniProtKB/TrEMBL

A7A156, B5VN86, C7GIV6, C8ZDD5, G2WIZ8, N1NZC6

Conserved Domains (1) summary

COG0612
Location:12 → 453

PqqL; Predicted Zn-dependent peptidase [General function prediction only]